Inhibitory Effects of Sterols Isolated from Chlorella vulgaris on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation and Tumor Promotion in Mouse Skin

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概要

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• Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of Chlorella vulgaris, a green alga. The hexane soluble fraction obtained from the methanol extract exhibited marked inhibitory activity from which were isolated two Δ^<5,7>-sterols (ergosterol and 7-dehydroporiferasterol), two Δ^<5,7,9(11)>-sterols [9(11)-dehydroergosterol and 7,9(11)-bisdehydroporiferasterol], two 5α, 8α-epidioxy-Δ^6-sterols (ergosterol peroxide and 7-dehydroporiferasterol peroxide), and a 7-oxo-Δ^5-sterol (7-oxocholesterol), among others. The Δ^<5,7>-sterols, 5α, 8α-epidioxy-Δ^6-sterols and 7-oxo-Δ^5-sterol inhibited TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.7 mg/ear. Furthermore, ergosterol peroxide markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a]anthracene-initiated mice.

• 公益社団法人日本薬学会の論文
• 1996-04-15

著者

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kanno H

  College Of Pharmacy Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• TAKIDO Michio

  College of Pharmacy, Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tai Takaaki

  Morishita Jintan Co. Ltd.

• Takido M

  College Of Pharmacy Nihon University

• Takido Michio

  College Of Pharmacy Nihon University

• Tamura T

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• TAMURA Toshitake

  College of Science and Technology, Nihon University

• KANNO Hiroshi

  College of Pharmacy, Nihon University

• KAMINAGA Tomohiro

  College of Pharmacy, Nihon University

• IZUMIDA Mitsuru

  College of Science and Technology, Nihon University

• SAKOH Takashi

  Chlorella Industry Co.,

• Izumida Mitsuru

  College Of Science And Technology Nihon University

• Kanno Hiroshi

  College Of Pharmacy Nihon University

• Kaminaga Tomohiro

  College Of Pharmacy Nihon University

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