Antitubercular Activity of Triterpenoids from Asteraceae Flowers(Pharmacognosy)

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概要

• 論文の詳細を見る

• Twenty-eight 3-hydroxy triterpenoids of taraxastane- (1-7), oleanane- (8-12), ursane- (13-15), lupane- (16, 18, 19), taraxane- (20), cycloartane- (21-25), tirucallane- (26-28), and dammarane-types (29) isolated from the non-saponifiable lipid fraction of the flower extract of chrysanthemum (Chrysanthemum morifolium) and one lupane-type 3α-hydroxy triterpenoid (17) derived from 16 were tested for their antitubercular activity against Mycobacterium tuberculosis strain H_<37>Rv using the Microplate Alamar Blue Assay (MABA). Fifteen compounds showed a minimum inhibitory concentration (MIC) in the range of 4-64 μg/ml, among which maniladiol (9 ; MIC 4 μg/ml), 3-epilupeol (17 ; 4 μg/ml), and 4, 5α-epoxyhelianol (27 ; 6 μg/ml) exhibited the highest activity. Cytotoxicity of compound 17 against Vero cells gave an IC_<50> value of over 62.5 μg/ml, suggesting some degree of selectivity for M. tuberculosis.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• FRANZBLAU Scott

  Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• UKIYA Motohiko

  C 964), University of Illinois at Chicago

• OKUDA Hiroki

  College of Science and Technology, Nihon University

• ZHANG Fangqiu

  College of Science and Technology, Nihon University

• YASUKAWA Ken

  Institute for Tuberculosis Research, College of Pharmacy (M

• SUZUKI Takashi

  C 964), University of Illinois at Chicago

• Zhang Fangqiu

  College Of Science And Technology Nihon University

• Okuda Hiroki

  College Of Science And Technology Nihon University

• Franzblau Scott

  Institute For Tuberculosis Research College Of Pharmacy (m

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

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