Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects

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概要

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•   Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4–9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09–0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1–3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91–93% inhibition at 1×103 mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

• 社団法人 日本農芸化学会の論文
• 2004-01-23

著者

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• TOKUDA Harukuni

  Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Banno Norihiro

  Ichimaru Pharcos Company Ltd.

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Nishino H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• 西村 弘行

  National Cancer Center Research Institute

• Nishino Hoyoku

  Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Watanabe Kensuke

  Ichimaru Pharcos Co. Ltd.

• Banno Norihiro

  Ichimaru Pharcos Co. Ltd.

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• HIGASHIHARA Hiroshi

  Department of Biochemistry, Kyoto Prefectural University

• WATANABE Kenji

  College of Science and Technology, Nihon University

• HASEGAWA Jun-ichi

  Ichimaru Pharcos Company Ltd.

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Tokuda Harukuni

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Hotta Hiroki

  Department Of Biochemistry Kyoto Prefectural University

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