Anti-tumor Promoting Effect of Glycosides from Prunus persica Seeds
スポンサーリンク
概要
- 論文の詳細を見る
Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (β-gentiobioside and β-D-glucoside) and benzyl alcohol glycosides (β-gentiobioside and β-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallo-catechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN<COOH<H.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Ito Hideyuki
Faculty of Pharmaceutical Sciences, Okayama University
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Fukuda T
Tokyo Metropolitan Medical Plant Garden
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Nishino H
Toho University School Of Pharmaceutical Sciences
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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MUKAINAKA Teruo
Kyoto Prefectural University of Medicine
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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Fukuda Toshiyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Mukainaka T
Kyoto Prefectural University Of Medicine
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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Tokuda H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Department Of Microbiology Faculty Of Medicine Kyoto University
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Tokuda Harukuni
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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Ito Hideyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Ito Hideyuki
Faculty Of Applied Biological Sciences Gifu University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Muranaka Takashi
Faculty Of Pharmaceutical Sciences Okayama University
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