Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark(Toxicology)
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概要
- 論文の詳細を見る
After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetrade-canoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro, koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene and promoted by TPA.
- 公益社団法人日本薬学会の論文
- 2003-09-01
著者
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伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Ito Hideyuki
Faculty of Pharmaceutical Sciences, Okayama University
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ISMAIL Intan
Faculty of Pharmaceutical Sciences, Okayama University
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Ismail Intan
Faculty Of Pharmaceutical Sciences Okayama University
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Nishino H
Toho University School Of Pharmaceutical Sciences
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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MUKAINAKA Teruo
Kyoto Prefectural University of Medicine
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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Mukainaka T
Kyoto Prefectural University Of Medicine
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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HIGASHIHARA Hiroshi
Department of Biochemistry, Kyoto Prefectural University
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Yoshida Takuji
Showa Pharmaceutical University
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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HIGASHIHARA Hiroshi
Kyoto Prefectural University of Medicine
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ENJO Fumio
Kyoto Prefectural University of Medicine
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Enjo Fumio
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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Hotta Hiroki
Department Of Biochemistry Kyoto Prefectural University
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Ismail I
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Ito Hideyuki
Faculty Of Applied Biological Sciences Gifu University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Muranaka Takashi
Faculty Of Pharmaceutical Sciences Okayama University
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