天然添加物の薬物代謝酵素の作用に及ぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Inhibition or induction of cytochrome P450 (CYP), which is responsible for the metabolism of drugs, can often cause interactions between foods and drugs. Therefore, concomitant intake of the food containing CYP-inhibitors or-inducers and certain drug may produce unexpected results. In this study, we systematically investigated the inhibitory effects of 30 natural food additives on CYP3A4 and CYP2C9 activities. Turmeric oleoresin and Kaoliang color exhibited relatively higher inhibition of CYP3A4 and CYP2C9 activities. Palm oil carotene and Marigold color inhibited particularly CYP3A4 and Tamarind and Monascus colors inhibited CYP2C9 activity. CYP inhibition assay-guided fractionation of Kaoliang color furnished flavonoid apigenin and high-molecular weight proanthocyanidin fraction having potent inhibitory activities to CYP3A4 and CYP2C9.
- 2010-08-23
著者
-
木村 友香
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
-
伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
-
波多野 力
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
-
伊東 秀之
岡山大学大学院医歯薬学総合研究科
-
Ito Hideyuki
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
-
Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
関連論文
- 天然添加物の薬物代謝酵素の作用に及ぼす影響
- スギヒラタケに含まれる特徴的な長鎖脂肪酸について
- Tannins and Related Polyphenols of Euphorbiaceous Plants. IX. Hydrolyzable Tannins with ^1C_4 Glucose Core form Phyllanthus flexuosus MUELL. ARG.
- 招待講演 クルミから得られたポリフェノールの構造と機能性 (第1回食品薬学シンポジウム講演要旨集)
- フトモモ科植物資源の研究: Kunzea ambiguaおよびEucalyptus cypellocarpaの成分と抗発癌プロモーション作用 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- B-15 阿仙薬のポリフェノール成分による品質評価(薬物代謝・天然物化学,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 阿仙薬のポリフェノール性成分による品質評価
- Cowaniin, a C-Glucosidic Ellagitannin Dimer Linked through Catechin from Cowania mexicana
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Conjugated Ketonic Fatty Acids from Pleurocybella porrigens
- P-236 CONJUGATED LONG-CHAIN FATTY ACIDS OF PLEUROCYBELLA PORRIGENS
- P-172 ANTIFUNGAL CONSTITUENTS FROM SANTALUM ALBUM OF INDIAN ORIGIN
- Urinary Excretion of Anthocyanins in Humans after Cranberry Juice Ingestion
- 木本性植物の組織培養によるタンニン生産と生合成
- Interaction of the Aryl Hydrocarbon Receptor with Several Constituents from Spinach and Komatsuna Extracts Determined Using in Vitro Bioassay
- Cypellogins A, B and C, Acylated Flavonol Glycosides from Eucalyptus cypellocarpa
- Two New Analogues of Trijugin-Type Limonoids from the Leaves of Sandoricum koetjape
- Chemical Constituents of Artemisia herba-alba Asso
- 天然ナノ分子タンニン : その構造と機能
- Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori
- ビワ葉の抗腫瘍性成分
- Proanthocyanidins and Related Compounds:Antileishmanial Activity and Modulatory Effects on Nitric Oxide and Tumor Necrosis Factor-α-Release in the Murine Macrophage-Like Cell Line RAW 264.7
- Tannins and Related Polyphenols,HIV Reverse Transcriptase Inhibitors, from Rosa woodsii
- P-87 山椒のMRSAに対する抗菌作用成分
- 天然添加物の薬物代謝酵素の作用に及ぼす影響
- 新規モノアシル化アスコルビン酸誘導体6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acidの分子内アシル基転位と酵素的加水分解(研究論文紹介)
- 少量の水を含むDMF中におけるアスコルビン酸2-グルコシドのプロテアーゼによるモノアシル化(研究論文紹介)
- New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt
- Combined Effect of Rebamipide and Ecabet Sodium on Helicobacter pylori Adhesion to Gastric Epithelial Cells
- Aromatic Constituents from the Heartwood of Santalum album L.
- Interaction of Polyphenols with Proteins : Binding of (-)-Epigallocatechin Gallate to Serum Albumin, Estimated by Induced Circular Dichroism
- ^F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors
- Functional Results of Sleeve Lobectomy for Tuberculous Bronchial Stenosis
- Phenolic Compounds from Dryopteris fragrans
- DRYOFRAGIN AND ASPIDIN PB, PISCICIDAL COMPONENTS FROM DRYOPTERIS FRAGRANS
- 30 ノボタン科植物のエラジタンニンオリゴマーの構造(口頭発表の部)
- Candida属真菌に対する各種精油及び精油成分の抗真菌作用，及びAmphotericin Bの抗真菌作用に及ぼす影響
- ウワウルシArctostaphylos uva-ursiの抗チロシナーゼ活性成分
- Effects of Mace and Nutmeg on Human Cytochrome P450 3A4 and 2C9 Activity
- New Hydrolyzable Tannins, Shephagenins A and B, from Shepherdia argentea as HIV-1 Reverse Transcriptase Inhibitors
- Tetrameric and Pentameric Ellagitannins from Monochaetum multiflorum
- Elaeagnatins A-G, C-Glucosidic Ellagitannins from Elaeagnus umbellata
- Polyphenols from the Leaves of Aronia melanocarpa
- Constituents of the Quercus suber Cork
- タンニンの活性酸素によるラット腹腔肥満細胞からのヒスタミン遊離に対する抑制効果
- Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark(Toxicology)
- Glycosides and Their Quantitative HPLC Analysis of Commercial Persicae Semen
- Anti-tumor Promoting Effect of Glycosides from Prunus persica Seeds
- Glycosides and Their Quantitative HPLC Analysis of Commercial Persicae Semen
- Polyphenols from Eriobotrya japonica and Their Cytotoxicity against Human Oral Tumor Cell Lines
- Marked Reduction in the Minimum Inhibitory Concentration (MIC) of β-Lactams in Methicillin-Resistant Staphylococcus aureus Produced by Epicatechin Gallate, an Ingredient of Green Tea (Camellia sinensis)
- Ichthyotoxic Phloroglucinol Derivatives from Dryopteris fragrans and Their Anti-tumor Promoting Activity
- Constituents of Geranium thunbergii SIEB. et ZUCC. XV. Modified Dehydroellagitannins, Geraniinic Acids B and C, and Phyllanthusiin F
- Phenolic Constituents of Cassia Seeds and Antibacterial Effect of Some Naphthalenes and Anthraquinones on Methicillin-Resistant Staphylococcus aureus
- Phenolic Constituents of Liquorice. VII. A New Chalcone with a Potent Radical Scavenging Activity and Accompanying Phenolics from Liquorice
- NEW PISCICIDAL TRITERPENES FROM IRIS GERMANICA
- Interaction of Polyphenolic Metabolites with Human Serum Albumin: A Circular Dichroism Study
- Effect of Helicobacter pylori Lipopolysaccharides on Human Polymorphonuclear Neutrophils and Endothelial Cells
- ホップ含有プレニルフラボノイドの化学療法剤としての可能性
- Chlorogenic Acid and Its Metabolite m-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells
- Characterization and Antioxidative Properties of Oligomeric Proanthocyanidin from Prunes, Dried Fruit of Prunus domestica L.
- Chlorogenic Acid and Its Metabolite m-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells
- Protective Effect of Japanese Green Tea Extract on Gnotobiotic Mice Infeeted with an Escherichia coli Ol57: H7 Strain
- 1-III-6 高分子触媒によるアスコルビン酸2-グルコシドのモノアシル化反応(一般演題要旨,日本ビタミン学会第63回大会講演要旨)
- Restriction Fragment Length Polymorphism in Helicobacter pylori Associated with Gastric Cancer and Duodenal Ulcer
- 薬用植物中の酸化型エラジタンニン成分とその生理活性
- 天然色素の分離と構造解析
- 薬用植物中の酸化型エラジタンニン成分とその生理活性
- Chemical Constituents of Artemisia herba-alba Asso
- Tannins and Related Polyphenols, HIV Reverse Transcriptase Inhibitors, from Rosa woodsii(Natural Medicine Note)
- Phenolic Compounds from Dryopteris fragrans(Natural Medicine Note)
- Polyphenols from the Leaves of Aronia melanocarpa
- Constituents of the Quercus suber Cork
- Glycosides and Their Quantitative HPLC Analysis of Commercial Persicae Semen
- Antioxidative Properties of Functional Polyphenols and Their Metabolites Assessed by an ORAC Assay
- Effect of CD4+ T-lymphocyte count on hospital outcome of elective general thoracic surgery patients with human immunodeficiency virus
- 高分子触媒によるDMF中アスコルビン酸2-グルコシドの部位選択的モノアシル化(研究論文紹介)
- 国立大学法人岡山大学大学院医歯薬学総合研究科 : 創薬生命科学専攻