Ichthyotoxic Phloroglucinol Derivatives from Dryopteris fragrans and Their Anti-tumor Promoting Activity
スポンサーリンク
概要
- 論文の詳細を見る
Two new ichthyotoxic compounds, aspidin PB (8) and dryofragin (9), along with three known phloroglucinol derivatives (1-3) and five terpenoids, were isolated from the whole herbs of Dryopteris fragrans by toxicity-directed fractionation using Oryzias latipes (Japanese name; medaka). The structures of the new compounds were determined by spectroscopic methods including 2D NMR techniques. Amongst the isolates, aspidin PB (8), dry-ofragin (9), and 1-5 exhibited potent ichthyotoxic activity against medaka with a median tolerance limit (TLm after 24 h) of 1.2-4.3 μg/ml. These compounds which are toxic to fish also had a potent inhibitory effect on the activation of Epstein-Barr virus early-antigen (EBV-EA) induced by tetradecanoyl phorbol 13-acetate, which is an in vitro short-term assay for anti-tumor promoting agents. Aspidin BB (2) and albicanol (4), which exhibited strong inhibitory effects on the EBV-EA activation, significantly suppressed an in vivo two-stage carcinogenesis on mouse skin.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Ito Hideyuki
Faculty of Pharmaceutical Sciences, Okayama University
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JIN Zhe-Xiong
Department of Hematology and Immunology, Kanazawa Medical University
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Jin Zhe
Department Of Chinese Medicine Heilongjiang Commercial College
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Jin Zhe-xiong
Department Of Chinese Medicine Heilongjiang Commercial College
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Nishino H
Toho University School Of Pharmaceutical Sciences
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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MURANAKA Takashi
Faculty of Pharmaceutical Sciences, Okayama University
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MORI Kazuko
Faculty of Pharmaceutical Sciences, Okayama University
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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Mukainaka T
Kyoto Prefectural University Of Medicine
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毛利 和子
Faculty Of Pharmaceutical Sciences Okayama University
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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Tokuda H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Department Of Microbiology Faculty Of Medicine Kyoto University
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Tokuda Harukuni
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Mori Kazuko
Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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Ito Hideyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Ito Hideyuki
Faculty Of Applied Biological Sciences Gifu University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Muranaka Takashi
Faculty Of Pharmaceutical Sciences Okayama University
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