Antitumor-Promoting Activities of Various Synthetic 1-O-Acyl-3-O-(6'-O-Acyl-β-D-Galactopyranosyl)-sn-Glycerols Related to Natural Product from Freshwater Cyanobacterium Anabaena flos-aquae f.flos-aquae

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概要

• 論文の詳細を見る

• 1-O-Acyl-3-O-(6'-O-acyl-β-D-galactopyranosyl-sn-glycerol, which was isolated from a nitrogen-fixing freshwater cyanobacterium, Anabaena flos-aquae f. flos-aquae, was synthesized by utilizing lipase-catalyzed acylation.The antitumor-promoting activities of these galactolipids were evaluated using a short-term in vitro assay of Epstein-Barr virus activation in Raji cells induced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA). The glyceroglycolipids which have a palmitoleoyl residue at the 1-O-position exhibited more potent activities than the others in this assay.

• 公益社団法人日本薬学会の論文
• 1996-07-15

著者

• TOKUDA Harukuni

  Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Nagatsu Akito

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Nishino Hoyoku

  Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura

• SAKAKIBARA Jinsaku

  Faculty of Pharmacy, Meijo University

• Murakami Nobutoshi

  Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)kyoto Pharmaceutical Univ

• Tokuda Harukuni

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• SHIRAHASHI Hideaki

  Faculty of Pharmaceutical Sciences, Nagoya City University

• MORIMOTO Takashi

  Faculty of Pharmaceutical Sciences, Nagoya City University

• TATTA Kazuhiro

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Tatta Kazuhiro

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Sakakibara Jinsaku

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Shirahashi H

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Morimoto Takashi

  Faculty Of Pharmaceutical Sciences Nagoya City University

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