Isolation and Characterization of Dinochrome A and B, Anti-carcinogenic Active Carotenoids from the Fresh Water Red Tide Peridinium bipes
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概要
- 論文の詳細を見る
Two epimeric carotenoids, named dinochromes A (2) and B (3), were isolated from the fresh water red tide Peridinium bipes, as anti-carcinogenic compounds. The stereostructure of dinochrome A and B were characterized to be (3S,5R,6R,3'S,5'R,8'R)- and (3S,5R,6R,3'S,5'R,8'S)-5',8'-epoxy-6,7-didehydro-5,6,5',8'-tetrahydro-β,β-carotene-3,5,3'-triol 3-0-acetate, respectively by ^lH- and ^13C-NMR, and circular dichroism (CD) data. Dinochromes A (2) and B (3) inhibit 12-0-tetradecanoyl phorbol 13-acetate (TPA)-stimulated ^32P-incorporation into the phosholipids of HeLa cells. Furthermore, dinochrome A was found to inhibit the proliferation of human malignant tumor cells, such as GOTO, OST and HeLa cells.
- 公益社団法人日本薬学会の論文
- 2002-12-01
著者
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Tsushima Miyuki
Kyoto Pharamceutical University
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Maoka Takashi
Kyoto Pharamceutical University
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