Antitumorigenic Activities of Chalcones (II). Photo-isomerization of Chalcones and the Correlation with Their Biological Activities
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概要
- 論文の詳細を見る
Some chalcones are known to be phototransformed in a solution from trans into cis isomers. 3-Hydroxy-3'-methylchalcone (3'Me-3-C) has been found to be isomerized from trans into cis by irradiation of daylight in the methanolic solution. The presence of a hydroxyl in the 2'- or 4-position in the trans-chalcone structure prevents phototransformation into cis isomers. The feasibility of phototransformation of chalcones was discussed using UV-spectral analysis. The phototransformed cis-3'Me-3-C showed more potent antitumorigenic activity than the original trans form.The generally recognized parallelism between antitumorigenic and antiinflammatory, activities was not observed in trans and cis 3'-Me- and 4'-Me-3C, which are antitumorigenic but inactive in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and arachidonic acid (AA)-induced mouse ear edema. However, inhibitory activity against ornithine-decarboxylase (ODC) was commonly observed in both naturally occurring and synthetic antitumorigenic chalcones.
- 社団法人日本薬学会の論文
- 1997-12-15
著者
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NAGATA NOBUYUKI
Research Laboratory, Minophagen Co.
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Inoue H
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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Nagata N
Minophagen Pharmaceutical Co. Ltd. Kanagawa Jpn
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Nagata Nobuyuki
Research Laboratory Minophagen Pharmaceutical Co. Ltd.
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Nagata Nobuyuki
Research Laboratories Of Minophagen Pharmaceutical Co. Ltd.
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IWATA Susumu
Research Laboratory, Minophagen Pharmaceutical Co., Ltd.
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SHIBATA Shoji
Shibata Laboratory of Natural Medicinal Materials, c
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NISHINO Takeshi
Research Laboratory, Minophagen Pharmaceutical Co., Ltd.,
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INOUE Hideo
Research Laboratory, Minophagen Pharmaceutical Co., Ltd.,
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SATOMI Yoshiko
Department of Biochemistry, Kyoto Prefectural University of Medicine
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NISHINO Hoyoku
Department of Biochemistry, Kyoto Prefectural University of Medicine
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Sogame Yoshio
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Shibata Shoji
Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.
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Shibata Shoji
Shibata Laboratory Of Natural Medicinal Materials
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Satomi Yoshiko
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Shibata S
Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.
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Iwata S
Research Laboratory Minophagen Pharmaceutical Co. Ltd.
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Iwata Susumu
Research Laboratory Minophagen Pharmaceutical Co.
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Nishino Takeshi
Res. Lab. Minophagen Pharmaceutical Co. Ltd.
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Inoue Hideo
Research Laboratory Minophagen Pharmaceutical Co. Ltd.
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Nishino Takeshi
Research Laboratory Minophagen Pharmaceutical Co. Ltd.
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Inoue Hideo
Research Laboratory Minophagen Pharmaceutical Co.
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SHIBATA Shoji
Shibata Laboratories of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co. Ltd.
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