Participation of Serotonin Capsaicin-Induced Mouse Ear Edema
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概要
- 論文の詳細を見る
We investigated the involvement of serotonin (5-HT) in mouse ear edema induced by topical application of capsaicin (250μg/ear). Application of capsaicin to the ear caused degranulation of mast cells in skin connective tissue. Capsaicin-induced ear edema was significantly inhibited by preadministration of 5-HT<SUB>2</SUB> receptor antagonists such as ketanserin (2 mg/kg, i.v.) and LY 53857 (1 mg/kg, i.v.), but not 5-HT<SUB>1</SUB>-, 5-HT<SUB>3</SUB>- and 5-HT<SUB>4</SUB>-receptor antagonists. Intradermal injection of α-methyl 5-HT (5-HT<SUB>2</SUB>-receptor agonist) and 5-HT into ear skin produced edema formation more potently than 8-OH-DPAT (5-HT<SUB>1A</SUB> agonist) and 2-methyl 5-HT (5-HT<SUB>3</SUB> agonist). 5-HT<SUB>2</SUB> antagonists markedly suppressed the edema response to 5-HT and its receptor agonists, whereas any antagonist for 5-HT<SUB>1</SUB>, 5-HT<SUB>3</SUB> and 5-HT<SUB>4</SUB>-receptors had no effect. Furthermore, 5-HT<SUB>2</SUB>-receptor antagonists partly prevented ear edema in response to substance P (SP), a putative mediator of capsaicin-induced edema, and compound 48/80, a releaser of vasoactive amines from mast cells. These results suggest that 5-HT released from mast cells is partly involved in the development of capsaicin-induced mouse ear edema via 5-HT<SUB>2</SUB> receptors in the ear skin.
- 社団法人 日本薬理学会の論文
- 1995-09-01
著者
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KOSHIHARA Yasuko
Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology
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Inoue Hideo
Research Laboratory Minophagen Pharmaceutical Co. Ltd.
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NAGATA Nouyuki
Research Laboratory, Minophagen Pharmaceutical Co.
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Nagata Nouyuki
Research Laboratory Minophagen Pharmaceutical Co.
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Koshihara Yasuko
Department Of Biosignal Research Tokeyo Metropolitan Institute Of Gerontology
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Inoue Hideo
Research Laboratory Minophagen Pharmaceutical Co.
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