Antisense Suppression of Collagen VI Synthesis Results in Reduced Expression of Collagen I in Normal Human Osteoblast-like Cells(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
A transient increase in collagen VI expression precedes the accumulation of collagen I associated with interleukin-4 (IL-4)-induced mineralization in human osteoblast-like cells. Transfection with an antisense oligonucleotide specific for α1 (VI) collagen mRNA was shown to attenuate mRNA levels of collagens VI and I. Incubating IL-4 treated cells with anti-collagen VI antiserum decreased expression of α1 (I) mRNA. The results suggest that collagen VI may regulate collagen I expression in the early phase of IL-4-induced mineralization.
- 社団法人日本農芸化学会の論文
- 2002-12-23
著者
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KOSHIHARA Yasuko
Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology
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HARUMIYA Satoru
Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research
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Harumiya Satoru
Department Of Nutrition Tokyo Metropolitan Institute Of Gerontology:(present Address)cell Signaling
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GIBSON Mark
Department of Pathology, University of Adelaide, Adelaide
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Gibson Mark
Department Of Pathology University Of Adelaide Adelaide
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Koshihara Yasuko
Department Of Biosignal Research Tokeyo Metropolitan Institute Of Gerontology
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HARUMIYA Satoru
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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- Antisense Suppression of Collagen VI Synthesis Results in Reduced Expression of Collagen I in Normal Human Osteoblast-like Cells(Biochemistry & Molecular Biology)
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