Pharmacological Activities of Glycyrrhetinic Acid Derivatives : Analgesic and Anti-Type IV Allergic Effects(Medeicinal Chemistry,Chemical)

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概要

• 論文の詳細を見る

• Glycyrrhetinic acid (Ia) and fourteen derivatives of glycyrrhetinic acid were examined to estimate the antinociceptive activity (tests on writhing and vascular permeability induced by 0.7% acetic acid) and anti-type IV allergic effects in mice. Among them, three dihemiphthalate compounds (IIf, IIIc, IVc) derived from, deoxoglycyrrhetol (IIa), showed strong inhibition of writhing and dye leakage at a dose of 6.25mg/kg (p.o.) and type IV allergy at 25mg/kg (i.p.). Among the hemisuccinate compounds, Ib, IIb and IIIb, had significant inhibitory effects on both writhing and vascular permeability, whereas IIc and IVb inhibited only one of the two responses, at 200mg/kg (p.o.). Four of the hemisuccinate compounds (IIb, c, IIIb, IVb) suppressed type IV allergy at 1OOmg/kg (i.p.). Glycyrrhetinic acid (Ia) and deoxoglycyrrhetol (IIa) showed no detectable inhibition in the screening tests at doses of less than 200mg/kg (i.p.).

• 公益社団法人日本薬学会の論文
• 1987-09-25

著者

• SAITO HIROSHI

  Department of Neurology, Tohoku University School of Medicine

• Shibata S

  National Medical Center Tokyo Jpn

• INOUE Hideo

  Research Laboratory, Minophagen Pharmaceutical Co., Ltd.,

• Shibata Shoji

  Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.

• MORI TAKEO

  Research Laboratory, Minophagen Pharmaceutical Co

• Mori Takeo

  Research Laboratory Minophagen Pharmaceutical Co

• Inoue H

  Hokkaido Univ. Sapporo Jpn

• Inoue Hideo

  Research Laboratory Minophagen Pharmaceutical Co. Ltd.

• Saito Hiroshi

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Inoue Hideo

  Research Laboratory Minophagen Pharmaceutical Co.

• Saito Hiroshi

  Department of Applied Chemistry, Graduate School of Engineering, Tohoku University

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