Na^+ and K^+ Dependence of L-Glutamate-Induced Suppression of Astrocyte Stellation in Culture
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概要
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We have recently found that L-glutamate suppresses astrocyte stellation induced by various stimuli, and that this effect of L-glutamate is mimicked by transportable giutamate uptake inhibitors. To test the possible role of the giutamate transporter in the regulation of astrocyte morphology, we investigated the Na^+ and K^+ dependence of this effect of L-glutamate. In astrocyte cultures obtained from the cerebral cortex of neonatal rats, the L-glutamate-induced suppression of astrocyte stellation was significantly attenuated in a low-Na^+/high-K^+ medium and by the Na^+-K^+ pump inhibitor ouabain. These results support that astrocyte morphology is affected by the activity of the Na^+-dependent glutamate transporter.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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ABE Kazuho
Department of Pharmacology, School of Pharmacy, Hoshi University
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ABE Kazuho
Faculty of Pharmacy, Musashino University
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Saito H
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Abe K
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo:japan
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Abe Kazuho
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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