Differential Effects of Microtubule Inhibitors on Axonal Branching and Elongation of Cultured Rat Hippocampal Neurons
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of microtubule inhibitors, taxol and colchicine, on the axonal branching and elongation in cultured rat hippocampal neurons. Taxol (50 nM) did not affect the morphology of neurons cultured under the control conditions, but significantly reduced the axonal branching stimulated by basic fibroblast growth factor. The axonal elongation stimulated by astrocyte-conditioned medium was not affected by the same concentration of taxol. Colchicine (10 nM) showed similar effects as taxol. These results suggest that microtubules play more important roles in axonal branching than in axonal elongation.
- 社団法人 日本薬理学会の論文
- 1995-06-01
著者
-
SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
-
Abe Kazuho
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Saito H
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Fukuoka University
-
Aoyagi A
Sankyo Co. Ltd. Tokyo Jpn
-
AOYAGI Atsushi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
-
Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
関連論文
- 5歳以下発症日本人1型糖尿病発症に関する免疫学的特徴に関する検討
- The Secular Trend in the Incidence of Subarachnoid Hemorrhage in Miyagi, Japan : 1979-1990
- Relationship between the Required Coefficient of Friction and Gait Initiation in Young Adults on a Low Friction Floor
- Frequencies of factors of metabolic syndrome at diagnosis in children with T2DM
- Modulation of Voltage-Gated Ca^ Current by 4-Hydroxynonenal in Dentate Granule Cells(Highlighted paper setected by Editor-in-cfiief)(Pharmacology)
- Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells
- Morphine augments excitatory synaptic transmission in the dentate gyrus through GABAergic disinhibition
- Defect in an Intrahepatic Degradation of Apolipoprotein B in Suncus: An Animal Model of Hypobetalipoproteinemia^1
- Role of Acyl Coenzyme A Cholesterol Acytransferase in Intrahepatic Processing of apo B-Lipoprotein in Suncus
- Defect in Assembly Process of Very-Low-Density Lipoprotein in Suncus Liver: An Animal Model of Fatty Liver
- Minimally Invasive Direct Coronary Artery Bypass Grafting for Third-Time Coronary Artery Revascularization
- SECRETORY MECHANISM AND PATHOPHYSIOLOGICAL ROLE OF HUMAN ATRIAL NATRIURETIC PEPTIDE IN MEN : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SPECIALITY OF ATRIAL FIBRILLATION IN WPW SYNDROME : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- Tuberous sclerosis, associated with renal cell carcinoma and angiomyolipoma, in a patient who developed endstage renal failure after nephrectomy
- Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient
- A female patient with malarial nephropathy
- CLINICAL STUDY ON THE SURGICAL TREATMENT OF SEPTAL ACCESSORY PATHWAY IN THE WPW SYNDROME : Arrhythmias (II) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Effects of fadrozole and leuprorelin acetate on aromatase activity and cell proliferation in a human breast cancer cell line (SK-BR-3)
- Inhibitory Effects of Catecholamines and Maternal Stress on Aromatase Activity in the Fetal Rat Brain
- Video-Assisted Blebectomy Using a Flexible Scope and a Bleb Implement
- The Relationship of Thyroid Cancer with Radiation Exposure from Nuclear Weapon Testing in the Marshall Islands
- The intensity of scattered light in turbid seawater is a major factor in the turbiditaxis of Japanese anchovy larvae
- Hepatocellular Carcinoma with a Sarcomatous Appearance : Report of a Case
- Direct Calculation of Source Parasitic Resistance in AlGaAs/GaAs HEMTs
- Pleural Involvement of Dialysis-Related Amyloidosis
- The PPARγ Ligand, 15d-PGJ_2, Attenuates the Severity of Cerulein-Induced Acute Pancreatitis
- Pulmonary pleomorphic carcinoma producing hCG
- Poorly Differentiated Adenocarcinoma with Signet-Ring Cell Carcinoma in a Hyperplastic Polyp of the Stomach : Report of a Case
- Fabry disease in patients receiving maintenance dialysis
- Pharmacological Activities of Glycyrrhetinic Acid Derivatives : Analgesic and Anti-Type IV Allergic Effects(Medeicinal Chemistry,Chemical)
- -P121-ENDOTHELIN INHIBITS RENIN RELEASE FROM ISOLATED RAT GLOMERULI : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells
- A Japanese Family with Ferroportin Disease Caused by a Novel Mutation of SLC40A1 Gene: Hyperferritinemia Associated with a Relatively Low Transferrin Saturation of Iron
- Body iron stores and Iron restoration rate in Japanese patients with chronic Hepatitis C as measured during therapeutic Iron removal revealed neither Increased body iron stores nor effects of C282y and H63d mutations on iron indices
- New Analytical Method for Pancreas and Liver Regeneration : Normalization of Streptozotocin-Induced Hyperglycemia by Retrograde Injection of Insulin Producing Cells
- FACTORS AFFECTING ON SODIUM METABOLISM IN SHR (S). A SERIAL OBSERVATION FROM 4 TO 20 WEEKS OF AGE : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- -0281-ELECTROPHYSIOLOGIC AND HEMODYNAMIC STUDY FOR ATRIAL FIBRILLATION IN WOLFF-PARKINSON-WHITE SYNDROME
- Secondary Hyperparathyroidism in Patients on Maintenance Hemodialysis : Study of Optimal Hemopurification and Parathyroidectomy
- Growth Interruption Effect on the Formation of CdSe/ZnSe Quantum Dots
- Generation and Evaluation of Post-Heated Zinc and Selenium Molecular Beams
- A Case of Malignant Pheochromocytoma with Holt-Oram Syndrome
- Improvement of Fatigue and Acceleration of Recovery from Stress-Induced Deficient Sexual Behavior in Mice Following Oral Administration of Soft-Shelled Turtle Powder
- Anti-tumor Effects of Orally Administered Soft-Shelled Turtle Powder in Mice
- Human T-Lymphotropic Virus Type-I Infection, Antibody Titers and Cause-specific Mortality among Atomic-bomb Survivors
- PTHrP and PTH/PTHrP Receptor Expressions in Human Endometrium
- The Role of Parathyroid Hormone-Related Protein in Intra-Tracheal Fluid
- The Effect of Cytokines on Parathyroid Hormone-Related Protein (PTH-rP) Production in Human Amnion Cells
- Molecular Beam Epitaxially Grown ZnSe(001) Surface Studied by the In Situ Observation of RHEED Intensity
- Effect of Residual Strain on the Splitting of Excitonic Luminescence Lines in Epitaxially Grown ZnSe/GaAs
- Antagonistic Effect of N - (3 - Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons
- The Effects of Ethanol and Crocin on the Induction of Long-Term Potentiation in the CA1 Region of Rat Hippocampal Slices
- Structural Requirement for Neurotrophic Activity of Spermine in Cultured Rat Hippocampal Neurons
- Cushing's Syndrome due to Bilateral Adrenocortical Adenomas with Unique Histological Features
- Na^+ and K^+ Dependence of L-Glutamate-Induced Suppression of Astrocyte Stellation in Culture
- Activin Selectively Abolishes Hippocampal Long-Term Potentiation Induced by Weak Tetanic Stimulation In Vivo
- Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus
- Furosemide : Sensitive Calcium Rise Induced by GABA_A : Receptor Stimulation in Cultures of Embryonic Rat Striatal Neurons
- Involvement of a Peripheral Mechanism in the Emesis Induced by Cardiac Glycosides in Suncus murinus
- Body Mass Index Negatively Influences Glycated Albumin, but not Glycated Hemoglobin, in Diabetic Patients
- AC Flashover Characteristics on Trapezoidal Contamination Models of Actual Insulators
- IS-54 Production of Macrophage Migration Inhibitory Factor(MIF)from Granulosa Cells at Ovulatory Phase
- Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients
- Marine Molluscs Collected from the Shallow Waters of Hainan Island, South China Sea, by China-Japan Joint Research in 1997
- K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma
- Malignant transformation of endometriosis : application of laser microdissection for analysis of genetic alterations according to pathological changes
- Intravascular Large B Cell Lymphoma Diagnosed by Senile Angioma Biopsy
- Intramolecular Carbostannylation of Allyl- and Vinylstannanes via a Radical Chain Process
- Hydroxy Group-Directed Homolytic Hydrostannylation of Alkenols with Dibutylchlorostannane
- Recent advances in non-invasive prenatal DNA diagnosis through analysis of maternal blood
- Flow Velocity Measurement in Rotating Cavities by using Particle Image Velocimetry
- Heat Transfer and Pressure Drop Characteristics of a Heat Exchanger with Vortex Generators
- CP2289,a New 5-HT_3 Receptor Ligand : Agonistic Activities on Gastroenteric Motility
- 3β-Hydroxysteroid Dehydrogenase Activity in Human Osteoblast-Like Cells
- A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
- Low Temperature Growth of ZnSe/GaAs Using Post-Heated Molecular Beams
- β_1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo
- Optimum Culture Conditions for Production of Exfoliative Toxin by Staphylococcus hyicus
- High-frequency stimulation of the basolateral amygdala facilitates the induction of long-term potentiation in the dentate gyrus in vivo
- Roles of GABA^A, NMDA and muscarinic receptors in induction of long-term potentiation in the medial and lateral amygdala in vitro
- Effect of Hexacyanoferrate(III) on Mycobacterium smegmatis 7Fe Ferredoxin: Further Evidence for Formation of a 6Fe(2×[3Fe-4S]) Ferredoxin
- Diffuse neuroaxonal leukodystrophy with spheroids of adult onset: MRI and pathological studies
- Influence of the Hand Breaking at Sideways Falls : Sharing Effective Mass and Impact Force (Proceedings of the 54th Meeting of Japan Society of Physiological Anthropology)
- P1-6 Protetive Movements in Descent Phase of Foward and Backward Falls(Proceedings of the 50th Meeting of Japan Society of Physiological Anthropology)
- TOXICOLOGICAL STUDY ON RATS FED HALOPERIDOL: 80 WEEK CHRONIC TOXICITY TEST
- Cold agglutinin disease by autoanti-i blood type antibody associated with B cell chronic lymphocytic leukemia
- The Current Concepts of "Normal Values" and "Clinical Reference Values" in the Clinical Laboratory : Trials for Determining Clinical Reference Values of the Tokai University Hospital
- Evaluation of L-Glutamate Clearance Capacity of Cultured Rat Cortical Astrocytes
- Effects on Anticipatory Postural Adjustments by Repetition of the Tiptoe Movement
- Gait Control in Young Adults Trained on a Low Friction Floor
- Intracellular Calcium Oscillation in Cultured Rat Hippcampal Neurons: A Model for Glutamatergic Neurotransmission
- Successful Treatment of Blunt Trauma Involving Complete Laceration of the Pancreas and Duodenum in a 7 - Year - Old Child: Report of a Case
- CD56^+ acute myeloid leukemia with monosomy 7
- Coronal Cementogenesis in Cattle Molar Teeth
- Differential Effects of Microtubule Inhibitors on Axonal Branching and Elongation of Cultured Rat Hippocampal Neurons
- P-8 Anticipatory Muscle Activation of the Low Extremities during Lateral Step Initiation(Proceedings of the 51st Meeting of Japan Society of Physiological Anthropology)
- L-Glutamate Suppresses Astrocyte Stellation Induced by Actin Breakdown in Culture
- Selective Cytotoxicity of Piperine on Cultured Rat Hippocampal Neurons in Comparison with Cultured Astrocytes : The Possible Involvement of Lipid Peroxidation
- The Relationship of Thyroid Cancer with Radiation Exposure from Nuclear Weapon Testing in the Marshall Islands
- Neonatal behavioral assessment scale as a predictor of later developmental disabilities of low birth-weight and/or premature infants
- Traumatic Pseudoaneurysm of the Subclavian Artery Following Anterior Dislocation of the Shoulder : A Report of a Surgical Case