Inhibitory Effect of Chalcone Derivatives on Recombinant Human Aldose Reductase

スポンサーリンク

概要

• 論文の詳細を見る

• More than fifty chalcone derivatives were synthesized to examine structure-activity relationships against human aldose reductase. Certain 2', 4'-dihydroxychalcone derivatives inhibited human aldose reductase activities, and 2', 4', 2,4-tetrahydroxychalcone and 2', 4', 2-trihydroxychalcone showed potent inhibitory activity with IC_<50> values of 7.4×10^<-9> M and 1.6×10^<-7> M, respectively. On the other hand, cis-form chalcones, which were isomerized from the original trans-forms by irradiation of daylight in methanol solution, promoted the activity of human aldose reductase.

• 社団法人日本薬学会の論文
• 1999-03-15

著者

• NAGATA NOBUYUKI

  Research Laboratory, Minophagen Co.

• Nagata N

  Minophagen Pharmaceutical Co. Ltd. Kanagawa Jpn

• Nagata Nobuyuki

  Research Laboratory Minophagen Pharmaceutical Co. Ltd.

• Nagata Nobuyuki

  Research Laboratories Of Minophagen Pharmaceutical Co. Ltd.

• IWATA Susumu

  Research Laboratory, Minophagen Pharmaceutical Co., Ltd.

• OMAE Ayako

  Meiji Pharmaceutical University

• YAMAGUCHI Shino

  Meiji Pharmaceutical University

• OKADA Yoshihito

  Meiji Pharmaceutical University

• SHIBATA Shoji

  Shibata Laboratory of Natural Medicinal Materials, c

• OKUYAMA Toru

  o Minophagen Pharmaceutical Co., Ltd.

• Shibata Shoji

  Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.

• Shibata Shoji

  Shibata Laboratory Of Natural Medicinal Materials

• Shibata S

  Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.

• Omae Ayako

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Iwata S

  Research Laboratory Minophagen Pharmaceutical Co. Ltd.

• Iwata Susumu

  Research Laboratory Minophagen Pharmaceutical Co.

• Okada Yoshihito

  Meiji College Of Pharmacy

• Okuyama Toru

  Meiji Pharmaceutical Univ. Tokyo Jpn

• SHIBATA Shoji

  Shibata Laboratories of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co. Ltd.

関連論文

• Antiviral Activities of Glycyrrhizin and Its Modified Compounds against Human Immunodeficiency Virus Type 1 (HIV-1) and Herpes Simplex Virus Type 1 (HSV-1) in Vitro
• Chemical Modification of Glycyrrhetinic Acid in Relation to the Biological Activities(Medicinal Chemistry,Chemical)
• 薬学教育と漢方(21)明治薬科大学
• Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on ^Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)
• ^C NMR SPECTRAL STUDIES OF ENTAGENIC ACID TO ESTABLISH ITS STRUCTURE
• 97 マメ科薬用植物サポニンの研究
• ^C Nuclear Magnetic Resonance Spectral Studies on Gleditsia Saponin C (GS-C)
• Inhibitory Effect of Chalcone Derivatives on Recombinant Human Aldose Reductase
• Antitumorigenic Activities of Chalcones (II). Photo-isomerization of Chalcones and the Correlation with Their Biological Activities
• Inhibitory Effect of Glycyrrhetinic Acid Derivatives on Capsaicin-Induced Ear Edema in Mice
• 非酵素的糖化抑制活性を有する天然薬物 (特集 グリケーション(糖化))
• The Inhibitory Effect of the Crude Extarct from a Seaweed of Dygenea simplex C. AGARDH on the in Vitro Cytopathic Activity of HIV-1 and It's Antigen Production
• Search for Naturally Occurring Substances to Prevent the Complications of Diabetes. II. Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation
• Further Studies on New Furostanol Saponins from the Bulbs of Allium macrostemon
• TWO NEW CYCLOARTANE-TYPE GLUCOSIDES, MONGHOLICOSIDE I AND II, FROM THE AERIAL PART OF ASTRAGALUS MONGHOLICUS BUNGE
• Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E_2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
• Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.^ Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion
• Characterization of an Apoptosis-Inducing Factor in Habu Snake Venom as a Glycyrrhizin (GL)-binding Protein Potently Inhibited by GL in VItro
• Biochemical Characterization of Selective Inhibitors for a Glycyrrhizin-binding Lipoxygenase from Soybeans
• Inhibitory Effect of a Lichen Polysaccharide Sulfate, GE-3-S, on the Replication of Human Immunodeficiency Virus (HIV) in Vitro
• Studies of Coumarins from the Chinese Drug Qianhu, XXVII : Structure of a New Simple Coumarin Glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum
• Pharmacological Activities of Glycyrrhetinic Acid Derivatives : Analgesic and Anti-Type IV Allergic Effects(Medeicinal Chemistry,Chemical)
• Casein Kinase II (CK-II)-Mediated Stimulation of HIV-1 Reverse Transcriptase Activity and Characterization of Selective Inhibitors in Vitro
• Biochemical Characterization of Recombinant HIV-1 Reverse Transcriptase (rRT) as a Glycyrrhizin-Binding Protein and the CK-II-Mediated Stimulation of rRT Activity Potently Inhibited by Glycyrrhetinic Acid Derivative
• Effects of Isoliquirithigenin on the Development of Preneoplastic Liver Lesions Caused by a Choline-Deficient, L-Amino Acid-Defined Diet and on the Urinary Bladder Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine in Rats
• Chemical Constituents of the Style of Zea mays L. with Glycation Inhibitory Activity
• The Favorable Effect of Style of Zea mays L. on Streptozotocin Induced Diabetic Nephropathy(Pharmacognosy)
• A New Flavone C-Glycoside from the Style of Zea mays L. with Glycation Inhibitory Activity
• Saponins Isolated from Allium chinense G. DON and Antitumor-promoting Activities of Isoliquiritigenin and Laxogenin from the Sama Drug
• PC52 ANTITUMOR-PROMOTING ACTIVITY OF GARLIC EXTRACT
• CALCIUM ANTAGONIST-LIKE ACTIONS OF COUMARINS ISOLATED FROM "QIAN-HU" ON ANAPHYLACTIC MEDIATOR RELEASE FROM MAST CELL INDUCED BY CONCANAVALIN A
• Studies on Cancer Chemoprevention by Traditional Folk Medicines XXV.^ Inhibitory Effect of Isoliquiritigenin on Azoxymethane-Induced Murine Colon Aberrant Crypt Focus Formation and Carcinogenesis
• The n-Butanol Soluble Part of Style of Zea mays L. (Gramineae) Ameliorates both Hyper- and Hypoalgesia in Streptozotocin-induced Diabetic Rats
• Inhibitory Effect of Traditional Turkish Folk Medicines on Aldose Reductase (AR) and Hematological Activity, and on AR Inhibitory Activity of Quercetin-3-O-methyl Ether Isolated from Cistus laurifolius L.(Pharmacognosy)
• PC51 INHIBITION OF TUMOR PROMOTER-INDUCED PHENOMENA BY THEPRINCIPLES OBTAINED FROM ALLIUM SPP.
• Identification of the licorice root stored in Shosoin based on the sequences of internal transcribed spacer (ITS) on nrDNA and the chemotaxonomic consideration
• HPLC analysis of coumarins in Turkish Seseli species (Umbelliferae)
• β_1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo
• Further Studies on the Structure of Polysaccharides from the Lichen Flavoparmelia caperata (L.) HALE
• Catalytic Activity of Isoborneol-Derived Sulfides in Asymmetric Addition of Diethylzinc to Benzaldehyde
• A New Triterpenoid Isolated from Lagerstronemia speciosa (L.) PERS.
• Studies on Index Compounds for HPLC Analysis of Glycyrrhiza flavescens Growing in Turkey
• Hematological Studied on Black Cumin Oil from the Seeds of Nigella sativa L.
• Isolichenan, an α-glucan isolated from lichen Cetrariella islandica, repaires impaired learning behaviors and facilitates hippocampal synaptic plasticity
• Changes of immunoreactive substance P level in mouse ear treated with capsaicin
• A New Flavonoid Glycoside from Pituranthos tortuosus Desf, Benth & Hook
• Three New Saponins as Index Compounds of Glycyrrhiza flavescens BOISS. Growing in Turkey
• Studies on Index Compounds for HPLC Analysis of Glycyrrhiza flavescens Growing in Turkey
• 伝統薬物による化学発がん予防に関する研究.XIX. : 黄〓を構成生薬とする漢方方剤の発がんプロモーション抑制作用
• 伝統薬物による化学発がん予防に関する研究 XVIII : ウコギ科植物の発がんプロモーター抑制効果
• 伝統薬物による化学発がん予防に関する研究.XVI : 〓血の改善に用いられる漢方方剤の発がんプロモーション抑制作用
• 海藻の生物活性に関する研究(III) : 発がんプロモーター抑制活性及びアルドース・レダクターゼ阻害活性
• 天然資源の化学発がん予防に関する研究XI : 薤白及び薤白を構成生薬とする漢方方剤の発がんプロモーション抑制作用
• 海藻水抽出物の抗エイズウイルス(HIV)活性
• Coumarins from Seseli gummiferum Pall, ex Sin. subsp. corymbosum P. H. Davis
• The Composition of Essential Oils from Seseli Species Growing in Turkey
• Using Chitin Column Chromatography, Isolation of 24-Hydroperoxy-24-vinyl-cholesterol from Sargassaceae Seaweeds
• Inhibitory Effect of Some Wild Plants in Akita on Melanin Biosynthesis
• Naturally Occurring Substances for Prevention of Complications of Diabetes. IV : Screening of Seavegetables for Inhibitory Effect on Aldose Reductase.
• Studies on the Antitumor-Promoting Activity of Naturally Occurring Substances. III. : Structure of a New Coumarin and Anti-Tumor-Promoter Activity of Coumarins from Angelicae Radix
• Flavonoids from Syneilesis aconitifolia(Natural Medicine Note)
• A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice

もっと見る 閉じる

スポンサーリンク