伝統薬物による化学発がん予防に関する研究.XIX. : 黄〓を構成生薬とする漢方方剤の発がんプロモーション抑制作用

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Anti-tumor-promoting activities of Kampo prescriptions containing "Huangqin (黄〓) as a major components; Wenqing Yin (温清飲) (1), Sanhuang-Xiexin Tang (三黄瀉心湯) (2), Shengjiang-Xiexin Tang (生姜瀉心湯) (3), Ganjiang-Huanglian-Huangqin-Renshen Tang (乾姜黄連黄〓人参湯) (4), Huangqin Tang (黄〓湯) (5), and Huangqin (黄〓) (6) were examined. Water extract prepared from the above prescriptions (1-5) and Huangqin (6) were orally administrated to ICR Mice and assayed by the two-stage mouse skin carcinogenesis test using 9,10-dimethyl-1,2-benzanthracene (DMBA) as an initiator and 12-Otetradecanoylphorbol-13-acetate (TPA) as a promoter. These prescriptions tested were converted a dosage of a man into a mouse had drunk with tap water every day. All test samples showed the inhibitory effects and the inhibition rates were 1: 23.0%, 2: 56.7%, 3: 66.7%, 4: 43.7%, 5: 47.1%, 6: 58.4%. Among prescriptions, 2 and 3 exhibited a strong effect. None of the prescriptions had any effect on the body weight of mice and showed any toxicity by oral administration. They may be effective for cancer chemoprevention.
日本生薬学会の論文
1998-12-20