天然資源の化学発がん予防に関する研究XI : 薤白及び薤白を構成生薬とする漢方方剤の発がんプロモーション抑制作用

概要

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Chinese Drug Xiebai (Gaihaku, bulbs of Allium chinense G. Don) showed an inhibitory effect on the TPA-enhanced radioactive inorganic phosphate (^<32>Pi) incorporation into phospholipids of HeLa cells. This crude drug, two Chinese medical prescriptions, Kuolon-Xiebai-Baiju Tang (Karogaihaku-hakushu-to), Zhishi-Xiebai-Guizhi Tang (Kijitsu-gaihaku-keishi-to), including Xiebai as a component, and another prescription Taone-chengqi Tang (Tokaku-joki-to), all employed for an Oketsu syndrome, were examined for their inhibitory effect on tumor-promoting activity. In the two stage skin tumor formation test in mice by using 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter and 7, 12-dimethylbenz [a] anthracene (DMBA) as initiator, Xiebai, Kuolon-Xiebai- Baiju Tang and Taone-Chengqi Tang showed a relatively strong effect, whereas Zhishi-Xiebai-Guizhi Tang was less active. Additionally, in the two stage lung tumor formation test in mice by using 5% glycerol as promoter and 4-nitroquinoline-l-oxide (4NQO) as initiator, Xiebei and the 3 prescriptions showed almost the same activities as in the skin tumor formation test.
日本生薬学会の論文
1995-09-20