海藻水抽出物の抗エイズウイルス(HIV)活性

概要

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Boiling water extracts of 25 species of marine algae were dialysed with dialysis membrane (Spectro/Por 6 MWCO : 50,000) to give dialysable and non-dialysable fractions. The aqueous extracts themselves and dialysable and non-dialysable fractions were assayed for their inhibitory activities on the growth of human immunodeficiency virus (HIV) in the MT-4 cell line by the preliminary microplate screening assay in vitro. Of the 75 samples assayed, 38 samples were found to inhibit the growth of HIV in vitro. The anti-HIV activity of the non-dialysed fraction of a red alga Callophyllis japonica was the most potent and those of red algae, Carpopeltis prolifera, Gelidium subcostatum and Gigartina intermedia, brown algae Ecklonia cava, Eisenia bicyclis, Hizikia fusiforme and Sargassum muticum and green alga Ulva pertura were moderately high. The polysaccharides from non-dialysable fractions of six algae including Callophyllis japonica were found to contain 2.2-7.1% of sulfate and to have average molecular weights of 1.24×10^5 to 1.91×10^6.
日本生薬学会の論文
1994-09-20