伝統薬物による化学発がん予防に関する研究.XVI : 〓血の改善に用いられる漢方方剤の発がんプロモーション抑制作用

概要

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To study the relation between the Oketsu syndrome or the stagnation of blood circulations (Yu-xue) and tumor promotion, we examined the anti-tumor promoting activity of Kampo prescriptions used for Oketsu syndrome ; Unsei-in (Wenqing Yin, 温清飲), Sanou-shashin-to (Sanhuang-Xiexin Tang, 三黄瀉心湯), Shikon-borei-to (Zicao-Muli Tang, 紫根牡蛎湯) which is clinically used for treatment of cancer and Sairei-to (Chailing Tang, 柴苓湯) used for treatment of edema. Daily oral administration at doses of 54.5, 9.0, 58.7, and 40.0 mg/100 mL/kg body weight in the two-stage mouse lung carcinogenesis test using glycerol as a promoter and 4-nitroquinoline-1 -oxide (4-NQO)-initiating carcinogen, these prescriptions as test sample showed inhibitory effects, and specially, Unsei-in exhibited a strong inhibitory effect on the promotion of 4 NQO-initiated tumor growth. The average body weight of mice of prescriptions administrated group did not decline. None of the four prescriptions showed toxicity by oral administration.
日本生薬学会の論文
1998-04-20