Antitumor-promoting activity of diallyl pentasulfide; a constituent of garlic

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概要

• 論文の詳細を見る

• 大蒜の成分であるDiallyl pentasulfide(DPS)の発がんプロモーション抑制効果を検討した。DPSは強力な発がんプロモーターで・あるTPAにより誘発されるEpstein-Barrウイルス早期抗原呈示に対し濃度依存的に阻害効果を示した。また,TPAにより誘導される放射牲無機リンの培養細胞リン脂質への取り込みにはとんど影響を与えなかったが,低濃度においては逆にTPAの効果を増強する傾l句が認められた。in vivoにおいてDPSは同じくTPAにより誘導されるオルニチン脱炭酸酵素活性を阻害し,また,マウス皮膚二段階発がんにおいて抗プロモーション効果を示した。その効果は,大蒜の発がん予防作用の一端を担っているものと思われる。

• 和漢医薬学会の論文
• 1999-08-25

著者

• 奥山 徹

  明治薬科大学生薬学研究室

• 奥山 徹

  明治薬科大学薬学部

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Nishino H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Kyoto Prefectural University Of Medicine

• BABA Masaki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• 奥山 徹

  明治薬科大学天然薬物学

• BABA Masaki

  明治薬科大学天然薬物学教室

• TAKASUKA Nobuo

  Dept. of Chemotherapy, National Cancer Center Research Institute

• ONOZUKA Mari

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• MASUDA Mitsuharu

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• MURAKOSHI Michiaki

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• SUGIMOTO Hajime

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• SATOMI Yoshiko

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• TOKUDA Harukuni

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• NISHINO Hoyoku

  Dept. of Biochemistry, Kyoto Prefectural University of Medicine

• Tokuda H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Tokuda Harukuni

  Department Of Microbiology Faculty Of Medicine Kyoto University

• Tokuda Harukuni

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Tokuda Harukuni

  Dept. Of Biochemistry Kyoto Prefectural University Of Medicine

• Onozuka Mari

  Dept. Of Biochemistry Kyoto Prefectural University Of Medicine

• Satomi Yoshiko

  Dept. Of Biochemistry Kyoto Prefectural University Of Medicine

• Takasuka Nobuo

  Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.

• Takasuka Nobuo

  Dept. Of Chemotherapy National Cancer Center Research Institute

• Murakoshi M

  Lion Corp. Kanagawa Jpn

• Masuda Mitsuharu

  Dept. Of Biochemistry Kyoto Prefectural University Of Medicine

• Murakoshi Michiaki

  Dept. Of Biochemistry Kyoto Prefectural University Of Medicine

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