Studies on Cancer Chemoprevention by Traditional Folk Medicines XXV.^<1)> Inhibitory Effect of Isoliquiritigenin on Azoxymethane-Induced Murine Colon Aberrant Crypt Focus Formation and Carcinogenesis

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概要

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• Isoliquiritigenin is a natural pigment with the simple chalcone structure, 4, 2', 4'-trihydroxychalcone. The effect of this compound on azoxymethane(AOM)-induced colonic aberrant crypt focus and tumor formation in ddY mice was examined. Administration of 15ppm of isoliquiritigenin in drinking water, significantly suppressed AOM-induced aberrant crypt focus formation(p<0.01), with an inhibitory ratio of 37.3%. Isoliquiritigenin also inhibited AOM-induced colon carcinogenesis by administration in a mixed diet. The average number of tumors was 14.6±8.9 items in the control group and were 7.3±7.3, 3.9±i5.6, 4.7±6.5 items in the 10, 100 and 250 ppm in the isoliquiritigenin treated groups, respectively. In histopathological studies, the tumors were identified as adenoma and adenocarcinoma, however, significant differences were not observed between the control group and isoliquiritigenin treated groups. These results indicated that isoliquiritigenin might be a potential chemopreventive agent against colon cancer.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Nishino H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Kyoto Prefectural University Of Medicine

• TAKAHASHI Tetsuyuki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• BABA Masaki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OKUYAMA Toru

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OKADA Yoshihito

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• BABA Masaki

  明治薬科大学天然薬物学教室

• Baba Masaki

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Okuyama Toru

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okuyama T

  Department Of Natural Medicine & Phytochemistry Meiji Pharmaceutical University

• ASANO Ryoya

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• TAKIGAMI Ikumi

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OHMURA Masayoshi

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• SUGIMOTO Hajime

  SafetyResearch, Development Research Laboratories, Kaken Pharmaceutical Co., Ltd.

• ARIKA Tadashi

  Safety Research, Development Research Laboratories, Kaken Pharmaceutical Co., Ltd.

• Asano Ryoya

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Arika Tadashi

  Safety Research Development Research Laboratories Kaken Pharmaceutical Co. Ltd.

• Takigami Ikumi

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Takahashi Tetsuyuki

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Ohmura M

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Sugimoto Hajime

  Safetyresearch Development Research Laboratories Kaken Pharmaceutical Co. Ltd.

• Okuyama Toru

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Okada Yoshihito

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

• Takahashi Tetsuyuki

  Department Of Molecular And Environmental Pathology Institute Of Health Biosciences University Of Tokushima Graduate School

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