Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.^<1)> Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

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概要

• 論文の詳細を見る

• 7-Isopentenyloxycoumarin (I) was isolated from Heracleum lanatum MICHX.(Umbelliferae). Compound I inhibited phospholipid metabolism and Epstein-Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoyl-phorbol-13-acetate(TPA)in 7, 12-dimethylbenz[a]anthracene.(DMBA)initiated mice. And it also suppressed or-nithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxy-coumarin is one of the effective compounds from natural resources for treating skin tumor formation.

• 社団法人日本薬学会の論文
• 2002-02-01

著者

• TOKUDA Harukuni

  Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• TSUDA Hiroyuki

  Chemotherapy

• Tsuda Hiroyuki

  Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences

• Tsuda H

  Keio Univ. Yokohama‐shi Jpn

• Nishino H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura

• Nishino Hoyoku

  Kyoto Prefectural University Of Medicine

• TAKASUKA Nobuo

  Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute

• BABA Masaki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OKUYAMA Toru

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• JIN Yongri

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• MIZUNO Atsuo

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• SUZUKI Hisaya

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OKADA Yoshihito

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Toriyama‐baba H

  Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute

• BABA Masaki

  明治薬科大学天然薬物学教室

• Baba Masaki

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Hiroyuki

  1st Dept. Pathol. Nagoya City Univ. Med. Sch.

• Tokuda Harukuni

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Jin Y

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Mizuno Atsuo

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okuyama Toru

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okuyama T

  Department Of Natural Medicine & Phytochemistry Meiji Pharmaceutical University

• Suzuki Hisaya

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Takasuka Nobuo

  Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.

• Tsuda H

  Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences

• Takasuka Nobuo

  Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute

• Okuyama Toru

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Okada Yoshihito

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

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