Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin
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概要
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Increasing attention is being paid to chemopreventive agents for individuals at high risk of cancer. We have concentrated on bovine lactoferrin (bLF), an 80kDa iron-binding glycoprotein known to have anti-microbial and immunoprotective effects. Lactoferrin is particularly abundant in colostrum, and is also present in tears, saliva and seminal and uterine secretions. However, only little is known regarding its influence on carcinogenesis. We have shown preventive effects of bLF and its fragment peptide, lactoferricin (bLFcin), consisting of a 25 amino acid sequence without iron binding capacity, on chemically-induced colon carcinogenesis in the rat and transplanted carcinoma cell metastasis in the mouse. The mechanisms are wide-spectrum, including elevation of caspase-1 and IL-18 in the small intestine, enhancement of the cell killing activity of cytotoxic T and natural killer (NK) cells, and anti-inflammatory and anti-angiogenic effects. It also inhibits the induction of liver CYP1A2, a carcinogen activating enzyme, and induces apoptosis in the colon epithelium of carcinogen treated rats. Thus, bLF possesses multi-functional potential to suppress carcinogenesis and is a good candidate for practical application in humans. (Communicated by Takashi SUGIMURA, M.J.A.)
著者
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FUKAMACHI Katsumi
Department of Molecular Toxicology, Nagoya City University
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TSUDA Hiroyuki
Department of Molecular Toxicology, Nagoya City University
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Fukamachi K
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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Fukamachi Katsumi
Dep. Of Molecular Toxicology Nagoya City Univ. Graduate School Of Medical Sciences
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Fukamachi Katsumi
Department Of Molecular Toxicology Nagoya City University
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Fukamachi Katsumi
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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Fukamachi Katsumi
名古屋市立大学 医学研究科分子毒性学分野
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TAKASUKA Nobuo
Cancer Prevention Basic Research Project, National Cancer Center Research Institute
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Iigo Masaaki
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
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Tanaka Harunari
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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TSUDA Hiroyuki
Chemotherapy
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Tsuda Hiroyuki
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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Tsuda H
Keio Univ. Yokohama‐shi Jpn
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Xu Jiegou
Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences
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SEKINE Kazunori
Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences
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OHKUBO Shigetoshi
Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences
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Toriyama‐baba H
Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute
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Tsuda Hiroyuki
1st Dept. Pathol. Nagoya City Univ. Med. Sch.
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Tsuda Hiroyuki
Department Of Electronics And Electrical Engineering Keio University
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Xu Jiegou
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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Takasuka Nobuo
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
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Tsuda H
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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Tsuda Hiroyuki
Dep. Of Molecular Toxicology Nagoya City Univ.
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Fujita K
Department Of Molecular Toxicology Nagoya City University Graduate School Of Medical Sciences
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IIGO Masaaki
Cancer Prevention Basic Research Project, National Cancer Center Research Institute
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FUKAMACHI Katsumi
Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka
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