EFFECT OF PYRIMIDINES, PURINES AND THEIR NUCLEOSIDES ON ANTITUMOR ACTIVITY OF 5-FLUOROURACIL AGAINST L-1210 LEUKEMIA
スポンサーリンク
概要
- 論文の詳細を見る
The chemotherapeutic action of 5-fluorouracil (5-FU) monotherapy on L-1210 leukemia in mice was compared with combinations of pyrimidines (uracil, uridine, deoxyuridine, cytosine, cytidine, deoxycytidine, thymine and thymidine) or purines (adenine, adenosine, deoxyadenosine, guanine, guanosine, deoxyguanosine and inosine) with 5-FU. The antitumor activity of 5-FU was enhanced by coadministration of uracil, thymine or guanosine, but the toxicity of the first two compounds was also enhanced. Only when 5-FU was administered with guanosine, was not only the antitumor activity but also the therapeutic ratio potentiated without increasing its toxicity. A time interval between the administration of 5-FU and guanosine diminished the survival effect. Therefore, the 5-FU-guanosine combination produced its optimal chemotherapeutic effect by simultaneous injection. The potentiation of antitumor effect of 5-FU by guanosine was prevented completely by cytidine or uridine. and partially by deoxyuridine, adenosine or deoxyadenosine.
- 公益社団法人日本薬学会の論文
著者
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Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
国立がんセンター
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Hoshi A
National Cancer Center Resarch Institute
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Iigo M
National Cancer Res. Inst. Tokyo
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Iigo Masaaki
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
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Iigo Masaaki
Pharmacology Division National Cancer Center Research Institute
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Iigo Masaaki
Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute
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Kuretani Kazuo
Pharmacology Division National Cancer Center Research Institute
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ANDO NAOKO
Pharmacology Division, National Cancer Center Research Institute
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Hoshi Akio
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij
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Ando Naoko
Pharmacology Division National Cancer Center Research Institute
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Ishiguro Masaji
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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