RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND ANTITUMOR ACTIVITY OF WITHAFERIN A ANALOGUES
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between chemical structure and antitumor activity of AB ring analogues of withaferin A was examined by cell growth inhibition in mouse leukemia L5178Y cells in vitro. The 5,6β-epoxy-4β-ol (5) and 5,6α-epoxy-4α-ol (6) with 1-keto-2-ene function and cholesterol side chain have antitumor activity. The 4,5-epoxy-6-hydroxyl compounds (9-16) were found to be equally or more active than corresponding 5,6-epoxy-4-hydroxyl analogues. The antitumor activities of the 4,5-epoxides paralleled the reactivities in ring opening reaction with acid. For the antitumor activity of withanolides, the unsaturated lactone in the side chain is important, and 1-keto-2-ene and epoxide functions were essential to elicit the activity.
- 公益社団法人日本薬学会の論文
著者
-
Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
-
Hoshi Akio
National Cancer Center Research Institute
-
KURETANI KAZUO
National Cancer Center Research Institute
-
Hoshi A
National Cancer Center Resarch Institute
-
Iigo Masaaki
Pharmacology Division National Cancer Center Research Institute
-
Kuretani Kazuo
Pharmacology Division National Cancer Center Research Institute
-
YOSHIDA MITSUZI
National Cancer Center Research Institute
-
Ishiguro Masaji
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
-
IKEKAWA NOBUO
Loboratory of Chemistry for Natural Products, Tokyo Institute of Technology
-
Ikekawa Nobuo
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
-
Yoshida Mitsuzi
Pharmacology Division National Cancer Center Research Institute
-
HOSHI Akio
National Cancer Center Resarch Institute
関連論文
- 5-Fluorouracil Derivatives. X. : Synthesis and Antitumor Activities of α-Alkoxyalkyl-5-fluorouracils
- Mode of Action of 5-Fluorocytidine and 5-Fluoro-2'-deoxycytidine in L5178Y Cells in Vitro
- 5-Fluorouracil Derivatives. XXII. Synthesis and Antitumor Activities of 1-Carbamoyl-5-fluorouracils
- 5-Fluorouracil Derivatives. XII. : Synthesis and Antitumor Activity of α-Alkylthiomethyl-, α-Alkylsulfinylmethyl-, α-Alkylsulfonylmethyl-, and α-Acylthiomethyl-5-fluorouracils(Medeicinal Chemistry,Chemical)
- Quantification of 5-fluorouracil and its metabolites in human serum, using liquid chromatography-mass spectrometry
- Decreased Levels of 2-Amino-3-methylimidazo[4,5-f]quinoline-DNA Adducts in Rats Treated with β-Carotene, α-Tocopherol and Freeze-dried Aloe
- ANTITUMOR ACTIVITY OF 1-ACYLOXYMETHYL DERIVATIVES OF 5-FLUOROURACIL AGAINST L1210 LEUKEMIA
- ANTITUMOR ACTIVITY OF ALKYLDISULFIDE DERIVATIVES OF 6-MERCAPTOPURINES AGAINST L-1210 LEUKEMIA
- ANTITUMOR ACTIVITY OF 1-ALKOXYCARBONYLALKYLCAR-BAMOYL-5-FLUOROURACIL DERIVATIVES BY ORAL ADMINISTRATION
- STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF PURIN-6-YL ALKYL DISULFIDES
- SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. X. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SEVERAL PURIN-6-YL BENZYL DISULFIDES AND THEIR RIBONUCLEOSIDES
- ANTITUMOR ACTIVITY OF DERIVATIVES OF NEPLANOCIN A IN VIVO AND IN VITRO
- ISOLATION AND CHARACTERIZATION OF THE MURINE LYMPHOMA L5178Y CELL LINE HIGHLY RESISTANT TO 5-FLUOROURACIL
- THE DIFFERENCE IN MECHANISM OF ACTION OF 5-FLUOROURACIL AND ITS NUCLEOSIDES IN L5178Y CELLS
- BIOLOGICAL ACTIVITY OF VITAMIN D_3 DERIVATIVES IN INDUCING DIFFERENTIATION OF HL-60 HUMAN PROMYELOCYTIC LEUKEMIA CELLS
- A Simple Method for Predicting Modes of Actions of Antitumor Agents
- POTENTIATION OF ANTITUMOR ACTIVITY OF 5-FLUORO-2', DEOXYURIDINE BY GUANOSINE-5'-MONOPHOSPHATE
- ANTITUMOR ACTIVITY OF ALKYLESTERS OF 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE (FDUMP) AGAINST MURINE LYMPHOMA L5178Y RESISTANT TO 5-FLUORO-2'-DEOXYURIDINE
- Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E_2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
- Down-regulation of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induceed CYP1A2 Expression Is Associated with Bovine Lactoferrin Inhibition of MeIQx-induced Liver and Colon Carcinogenesis in Rats
- Organotropic Chemopreventive Effects of n-3 Unsaturated Fatty Acids in a Rat Multi-organ Carcinogenesis Model
- Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors
- Activation of Intestinal Mucosal Immunity in Tumor-bearing Mice by Lactoferrin
- Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat
- Cancer Prevention by Natural Compounds
- IMPROVEMENT OF THERAPEUTIC EFFECT OF 5-FLUOROURACIL BY OROTIC ACID
- EFFECT OF PYRIMIDINES, PURINES AND THEIR NUCLEOSIDES ON ANTITUMOR ACTIVITY OF 5-FLUOROURACIL AGAINST L-1210 LEUKEMIA
- EXCRETION OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL IN URINE OF MICE
- ANTITUMOR ACTIVITY OF METABOLITES OF 1-HEXYLCAR-BAMOYL-5-FLUOROURACIL AND RELATED COMPOUNDS AGAINST L1210 LEUKEMIA IN VIVO AND L5178Y LYMPHOMA CELLS IN VITRO
- RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND ANTITUMOR ACTIVITY OF WITHAFERIN A ANALOGUES
- DISTRIBUTION OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL AND 5-FLUOROURACIL BY ORAL ADMINISTRATION IN MICE
- ANTITUMOR ACTIVITY OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL IN LEWIS LUNG CARCINOMA AND B16 MELANOMA
- ANTITUMOR AGENTS IN NUCLEIC ACID ANALOGUES
- U1B3.3 monoclonal antibody recognizes a precursor of NK1.1+ cytotoxic T cells generated by interleukin-2
- FURTHER STUDY ON THE RELATION BETWEEN AREA AND DESOXYRIBONUCLEIC ACID CONTENT OF THE MAMMARY GLAND IN MICE
- DIFFERENCE IN MAMMARY GLAND SUSCEPTIBILITY TO PROLACTIN BETWEEN A HIGH AND A LOW MAMMARY TUMOR STRAINS OF MICE
- RELATIONS BETWEEN AREA AND DESOXYRIBONUCLEIC ACID CONTENT OF THE MAMMARY GLAND IN MICE
- Synergistic inhibition of the growth of adenocarcinoma 755 by the combination of interleukin-2 and interferon-.BETA..