ANTITUMOR ACTIVITY OF 1-ACYLOXYMETHYL DERIVATIVES OF 5-FLUOROURACIL AGAINST L1210 LEUKEMIA

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概要

• 論文の詳細を見る

• Antitumor activity of 15 1-acyloxymethyl derivatives of 5-fluorouracil was examined by both intraperitoneal injection and oral administration in L1210 leukemia system. Therapeutic ratio for dodecanoyloxymethyl derivative by intraperitoneal injection was 23 which was greater than that for 5-fluorouracil (11). On the other hand, undecanoyloxymethyl derivative of 5-fluorouracil showed the highest therapeutic ratio (5. 8) when administered orally which was greater than that for 5-fluorouracil (1.9) and 1-(2-tetrahydrofuryl)-5-fluorouracil (1.0).

• 社団法人日本薬学会の論文

著者

• INOMATA Motoko

  Pharmacology Division, National Cancer Center Research Institute

• Kanzawa Fumihiko

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

• Kanzawa Fumihiko

  Pharmacology Division National Cancer Center Research Institute

• Hoshi Akio

  Pharmacology Division National Cancer Center Research Institute

• Hoshi Akio

  国立がんセンター

• Inomata Motoko

  Pharmacology Division National Cancer Center Research Institute

• Inomata Motoko

  National Cancer Center Research Institute

• Hoshi A

  National Cancer Center Resarch Institute

• Iigo M

  National Cancer Res. Inst. Tokyo

• Iigo Masaaki

  Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.

• Iigo Masaaki

  Pharmacology Division National Cancer Center Research Institute

• Iigo Masaaki

  Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute

• Kuretani Kazuo

  Pharmacology Division National Cancer Center Research Institute

• Hoshi Akio

  Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij

• Ishiguro Masaji

  Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology

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