SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. X. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SEVERAL PURIN-6-YL BENZYL DISULFIDES AND THEIR RIBONUCLEOSIDES
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概要
- 論文の詳細を見る
Reaction of S-benzylthioisothiouronium hydrochloride with 6-mercaptopurine (1), 9-β-D-ribofuranosyl-6-mercaptopurine (2), 6-thioguanine (3) and 9-β-D-ribofuranosyl-6-thioguanine (4) afforded corresponding benzyl disulfide derivatives (5-8) in good yield. These compounds were converted easily to parent mercapto derivatives when they were treated with various reducing agents such as β-mercaptoethanol. Antitumor activity of compound 5 was higher than that of 1 both in ascites Sarcoma 180 and in Nakahara-Fukuoka sarcoma systems. However, toxicity and immunosuppressive activity of compound 5 and 6 were higher than those of 1 and 2,respectively.
- 公益社団法人日本薬学会の論文
著者
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INOMATA Motoko
Pharmacology Division, National Cancer Center Research Institute
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Hoshi Akio
National Cancer Center Research Institute
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Inomata Motoko
Pharmacology Division National Cancer Center Research Institute
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Inomata Motoko
National Cancer Center Research Institute
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FUKUOKA FUMIKO
National Cancer Center Research Institute
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SANEYOSHI MINEO
Faculty of Pharmaceutical Sciences, Hokkaido University
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SEKINE TERUAKI
National Cancer Center Research Institute
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Saneyoshi Mineo
Faculty Of Pharmaceutical Sciences Hokkaido University
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HOSHI Akio
National Cancer Center Resarch Institute
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