A Topoisomerase II Inhibitor, NK109, Induces DNA Single- and Double-strand Breaks and Apoptosis

スポンサーリンク

概要

• 論文の詳細を見る
• 1996-10-31

著者

• OKA MIKIO

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Saijo N

  Division Of Internal Medicine National Cancer Center Hospital East

• Saijo Nagahiro

  国立医薬品食品衛生研究所

• Saijo N

  Medical Oncology National Cancer Center Hospital

• Nishio K

  Department Of Genome Biology Kinki University School Of Medicine

• Kuzuya Nobuaki

  国立医薬食品衛生研究所 薬物応答予測プロジェクト

• NISHIO Kazuto

  Pharmacology Division, National Cancer Center Research Institute

• ARIOKA Hitoshi

  Pharmacology Division, National Cancer Center Research Institute

• ISHIDA Tomoyuki

  Pharmacology Division, National Cancer Center Research Institute

• FUKUMOTO Hisao

  Pharmacology Division, National Cancer Center Research Institute

• FUKUOKA Kazuya

  Pharmacology Division, National Cancer Center Research Institute

• KUROKAWA Hirokazu

  Pharmacology Division, National Cancer Center Research Institute

• Saijo Nagahiro

  Pharmacology Division, National Cancer Center Research Institute

• FUKUDA Minoru

  Department of Medical Oncology, National Cancer Center Hospital

• INOMATA Motoko

  Pharmacology Division, National Cancer Center Research Institute

• KANZAWA Fumihiko

  Pharmacology Division, National Cancer Center Research Institute

• Fukumoto H

  National Cancer Center Res. Inst.

• Fukumoto Hisao

  国立がんセンター

• Fukumoto Hisao

  Pharmacology Division Natonal Cancer Center Research Instiute

• Fukumoto Hisao

  Pharmacology Division National Cancer Center Research Institute

• Kanzawa Fumihiko

  国立がんセンター

• Kanzawa Fumihiko

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

• Kanzawa Fumihiko

  Pharmacology Division National Cancer Center Research Institute

• Ishida Tomoyuki

  Pharmacology Division National Cancer Center Research Institute

• Ishida Tomoyuki

  国立がんセンター

• Arioka H

  National Cancer Center Res. Inst.

• Arioka Hiroshi

  国立がんセンター

• Arioka Hitoshi

  国立がんセンター中央病院

• Arioka Hitoshi

  Pharmacology Division National Cancer Center Research Institute

• Fukuoka K

  National Cancer Center Res. Inst.

• Inomata Motoko

  Pharmacology Division National Cancer Center Research Institute

• Inomata Motoko

  国立がんセンター中央病院

• Kurokawa Hirokazu

  Pharmacology Division National Cancer Center Research Institute

• Kurokawa Hirokazu

  国立がんセンター

• Nishio Kazuto

  Pharmacology Division National Cancer Center Research Institute

• Saijo Nagahiro

  Pharmacology Division National Cancer Center Research Institute

• Fukuda Minoru

  Department Of Medical Oncology National Cancer Center Hospital

• Oka Mikio

  Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Fukuda Minoru

  Department Of Anatomy Kyorin University School Of Medicine

• Fukuoka Kazuya

  Pharmacology Division National Cancer Center Research Institute

関連論文

• Genetic Variations and Haplotypes of ABCC2 Encoding MRP2 in a Japanese Population
• Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
• Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
• Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2)
• Autoimmune reactivity of sera to hepatocyte plasma membrane in type 1 autoimmune hepatitis
• 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
• Twenty Novel Genetic Variations and Haplotype Structures of the DCK Gene Encoding Human Deoxycytidine Kinase (dCK)
• Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population
• Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects : SLCO1B1^*17 is More Prevalent Than ^*15
• Genetic Variations and Haplotype Structures of the ABC Transporter Gene ABCC1 in a Japanese Population
• Fourteen Novel Genetic Variations and Haplotype Structures of the TYMS Gene Encoding Human Thymidylate Synthase (TS)
• 日本人における Denaturing HPLC を用いた Thiopurine S-Methyltransferase 遺伝子の新規SNPスクリーニング
• 日本人におけるヒトSLC29A1の新規遺伝子多型の同定
• Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population
• Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
• Genetic Polymorphisms of UGT1A6 in a Japanese Population
• Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
• Non-synonymous Single Nucleotide Alterations Found in the CYP2C8 Gene Result in Reduced in Vitro Paclitaxel Metabolism
• Three Novel Single Nucleotide Polymorphisms in UGT1A9
• Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
• Three novel single nucleotide polymorphisms in UGT1A10
• Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples
• Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor
• Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells
• A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer
• Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway
• Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models
• Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
• Reversal of Cisplatin Resistance by the 1,4-Benzothiazepine Derivative, JTV-519
• CPT-11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver
• Enhancement of Cisplatin Sensitivity in High Mobility Group 2 cDNA-transfected Human Lung Cancer Cells
• Characterization of a Human Small-cell Lung Cancer Cell Line Resistant to a New Water-soluble Camptothecin Derivative, DX-8951f
• Preferential Binding of E7010 to Murine β3-Tubulin and Decreased β3-Tubulin in E7010-resistant Cell Lines
• In vitro Enhancement of Antitumor Activity of a Water-soluble Duocarmycin Derivative, KW-2189, by Caffeine-mediated DNA-repair Inhibition in Human Lung Cancer Cells
• p16^ Expression Is Associated with the Increased Sensitivity of Human Non-small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors
• Interferon-γ-inducing Factor Gene Transfection into Lewis Lung Carcinoma Cells Reduces Tumorigenicity in vivo
• Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ-Glutamylcysteine Synthetase Gene
• A Topoisomerase II Inhibitor, NK109, Induces DNA Single- and Double-strand Breaks and Apoptosis
• Effect of suramin on cdc2 kinase activity of the purified enzyme and from the crude extracts from lung cancer cells
• Correlation of Gene-specific Damage with Cisplatin between Human Adenocarcinoma Cells and Peripheral Blood Mononuclear Cells Analyzed by Polymerase Chain Reaction-stop Assay
• Development and characterization of an antibody specifically recognizing a mutant EGFR (L858R) protein expressed frequently in non-small cell lung cancer
• High sensitivity detection of epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patients
• A Limited Sampling Model for Estimating Pharmacokinetics of CPT-11 and Its Metabolite SN-38
• 日本人におけるABCC3遺伝子の多型解析
• Enhancement of in vivo Antitumor Activity of a Novel Antimitotic 1-Phenylpropenone Derivative, AM-132, by Tumor Necrosis Factor-α or Interleukin-6
• Intracellular Carboxyl Esterase Activity Is a Determinant of Cellular Sensitivity to the Antineoplastic Agent KW-2189 in Cell Lines Resistant to Cisplatin and CPT-11
• ANTITUMOR ACTIVITY OF 1-ACYLOXYMETHYL DERIVATIVES OF 5-FLUOROURACIL AGAINST L1210 LEUKEMIA
• ANTITUMOR ACTIVITY OF ALKYLDISULFIDE DERIVATIVES OF 6-MERCAPTOPURINES AGAINST L-1210 LEUKEMIA
• ANTITUMOR ACTIVITY OF 1-ALKOXYCARBONYLALKYLCAR-BAMOYL-5-FLUOROURACIL DERIVATIVES BY ORAL ADMINISTRATION
• STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF PURIN-6-YL ALKYL DISULFIDES
• SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. X. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SEVERAL PURIN-6-YL BENZYL DISULFIDES AND THEIR RIBONUCLEOSIDES
• ISOLATION AND CHARACTERIZATION OF THE MURINE LYMPHOMA L5178Y CELL LINE HIGHLY RESISTANT TO 5-FLUOROURACIL
• ANTITUMOR ACTIVITY OF ALKYLESTERS OF 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE (FDUMP) AGAINST MURINE LYMPHOMA L5178Y RESISTANT TO 5-FLUORO-2'-DEOXYURIDINE
• Immunotherapy by intra-peritoneal intra-peritoneal injection of interleukin-2 gene transduced ling cancer cell line.
• IMPROVEMENT OF THERAPEUTIC EFFECT OF 5-FLUOROURACIL BY OROTIC ACID
• Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients
• What is the most informative pharmacodynamic model for paclitaxel (T)? : a 3 hour-infusion vs. 24-hour infusion.
• Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer
• High-risk populations for nasal carriage of methicillin-resistant Staphylococcus aureus
• Bronchial Artery Aneurysm as a Cause of Atelectasis
• P-Glycoprotein Is Positively Correlated with p53 Protein Accumulation in Human Colorectal Cancers
• Gene Mutation Analysis and Quantitation of DNA Topoisomerase I in Previously Untreated Non-small Cell Lung Carcinomas
• Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan
• Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer
• Tumor response to chemotherapy : The validity and reproducibility of RECIST guidelines in NSCLC patients
• INHIBITORY EFFECTS OF REPEATED INTRAVENOUS INJECTIONS OF DEXAMETHASONE ON PULMONARY TOXICITY OF A NEW MITOMYCIN C ANALOGUE, KW-2149, IN A NOVEL RAT MODEL
• Inhibitory effects of dexamethasone on pulmonary toxicity of a new mitomycin C analogue KW-2149 in a novel rat model.
• Prospective Evaluation of the Feasibility of Cisplatin-based Chemotherapy for Elderly Lung Cancer Patients with Normal Organ Functions
• Birth Cohort Effects on Incidence of Lung Cancers : A Population-based Study in Nagasaki, Japan
• ANTITUMOR ACTIVITY OF QUINOCARMYCIN AGAINST CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
• N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
• Enhanced Anti-tumor Effect of Trastuzumab in Combination with Cisplatin
• Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: A retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A)
• Phase I Study of Paclitaxel by Three-hour Infusion : Hypotension Just after Infusion Is One of the Major Dose-limiting Toxicities
• ANTITUMOR ACTIVITY OF METABOLITES OF 1-HEXYLCAR-BAMOYL-5-FLUOROURACIL AND RELATED COMPOUNDS AGAINST L1210 LEUKEMIA IN VIVO AND L5178Y LYMPHOMA CELLS IN VITRO
• Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
• COMPARATIVE STUDIES OF PULSE AND CONTINUOUS EXPOSURE IN HUMAN TUMOR CLONOGENIC ASSAY
• THE USE OF HUMAN TUMOR CLONOGENIC ASSAY IN PREDICTING COMBINATION EFFECT OF CISPLATIN PLUS VINDESINE IN CARCINOMA OF THE LUNG
• Intratumoral Administration of Tumor Necrosis Factor-α for Malignant Gliomas : Two Case Reports
• Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification
• Genetic Polymorphisms of Copper- and Platinum Drug-efflux Transporters ATP7A and ATP7B in Japanese Cancer Patients
• Ethnic Differences of two Non-synonymous Single Nucleotide Polymorphisms in CDA Gene
• Translational and clinical studies of target-based cancer therapy
• A Solitary Bronchial Papilloma with Malignant Changes
• Effect of probiotic bacterial strains of Lactobacillus, Bifidobacterium, and Enterococcus on enteroaggregative Escherichia coli
• A Computational Model for Quantitative Analysis of Cell Cycle Arrest and Its Contribution to Overall Growth Inhibition by Anticancer Agents
• IN VITRO CHEMOSENSITIVITY PATTERNS OF CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
• Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition
• 384 Development of Resistance to Anticancer Drugs in NIH3T3 Cells Transfected with c-myc and/or c-H-ras Genes.
• A Pharmacokinetic and Pharmacodynamic Analysis of CPT-11 and Its Active Metabolite SN-38
• Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers
• Massive Adrenal Hemorrhage Secondary to Metastasis of Lung Cancer
• Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
• Genetic Polymorphisms of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis
• Plasma concentrations of VCAM-1 and PAI-1 : A predictive biomarker for post-operative recurrence in colorectal cancer
• Evaluation of Bronchoalveolar Lavage as a Diagnostic Procedure for Primary Pulmonary B-cell Lymphoma
• FURTHER STUDY ON THE RELATION BETWEEN AREA AND DESOXYRIBONUCLEIC ACID CONTENT OF THE MAMMARY GLAND IN MICE

もっと見る 閉じる

スポンサーリンク