COMPARATIVE STUDIES OF PULSE AND CONTINUOUS EXPOSURE IN HUMAN TUMOR CLONOGENIC ASSAY
スポンサーリンク
概要
- 論文の詳細を見る
To assess the influence of different schedules of drug exposure in human tumor clonogenic assay on in vitro cytotoxicity of antitumor drugs, the in vitro sensitivities of a human carcinoma cell line, PC-9,to various antitumor drugs were measured by using two different procedures : exposure was either by pulse for 1 h prior to plating or continuous throughout the period of growth in agar. Marked differences between the two procedures in testing actinomycin D, etoposide, 5-fluorouracil, vinblastine and vindesine but not in adriamycin, daunomycin, melphalan, nimustine and ranomustine were observed. The former and the latter were classified as schedule dependent drugs and a schedule independent drugs, respectively. In this study, the schedule dependency of in vitro drug response appears to be related mainly to time-dependency and partially to other factors, such as stability during culture in medium.
- 公益社団法人日本薬学会の論文
著者
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Saijo N
Division Of Internal Medicine National Cancer Center Hospital East
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Saijo Nagahiro
国立医薬品食品衛生研究所
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Saijo N
Medical Oncology National Cancer Center Hospital
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Saijo Nagahiro
Pharmacology Division, National Cancer Center Research Institute
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Kanzawa Fumihiko
国立がんセンター
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Kanzawa Fumihiko
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
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Kanzawa Fumihiko
Pharmacology Division National Cancer Center Research Institute
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Fukuoka K
National Cancer Center Res. Inst.
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Saijo Nagahiro
Pharmacology Division National Cancer Center Research Institute
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CHIANG CHIDER
Pharmacology
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MATSUSHIMA YUKA
Pharmacology
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NAKANO HIDEHIKO
Pharmacology
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NAKAGAWA KAZUHIKO
Pharmacology
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TAKAHASHI HIDENOBU
Pharmacology
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SASAKI YASUTSUNA
Pharmacology
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Nakagawa Kazuhiko
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
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Sasaki Y
Mitsubishi Kasei Corporation Research Center:school Of Pharmaceutical Sciences Kitasato University
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Takahashi H
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Chiang Chider
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
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Nakano H
Department Of Applied Chemistry Himeji Institute Of Technology
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Matsushima Y
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
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