THE USE OF HUMAN TUMOR CLONOGENIC ASSAY IN PREDICTING COMBINATION EFFECT OF CISPLATIN PLUS VINDESINE IN CARCINOMA OF THE LUNG

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概要

• 論文の詳細を見る

• By using a human tumor clonogenic assay, cisplatin plus vindesine regimen was evaluated in 17 carcinoma of the lung. The cisplatin (0.2 μg/ml) plus vindesine (0.005 μg/ml) combination was synergistic and additive cell killing in 10 and 4,respectively, of 17 specimens. On the other hand, only three specimens showed antagonistic cell killing from this drug combinatin. Our results indicated that this in vitro assay provides a new method which can predict the effects of the combination of drugs on individual patients.

• 公益社団法人日本薬学会の論文

著者

• Saijo N

  Division Of Internal Medicine National Cancer Center Hospital East

• Saijo Nagahiro

  国立医薬品食品衛生研究所

• Saijo N

  Medical Oncology National Cancer Center Hospital

• Kanzawa Fumihiko

  国立がんセンター

• Kanzawa Fumihiko

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

• Fukuoka K

  National Cancer Center Res. Inst.

• Saijo Nagahiro

  Department Of Internal Medicine National Cancer Center Hospital

• Sasaki Y

  Mitsubishi Kasei Corporation Research Center:school Of Pharmaceutical Sciences Kitasato University

• ISHIHARA JUNICHI

  Pharmacology Division, National Cancer Center Research Institute

• MIYAZAWA NAOTO

  Department of Surgery Division National Cancer Center Hospital

• Shimizu E

  Osaka City Univ. Osaka‐shi Jpn

• Miyazawa Naoto

  Surgery Division National Cancer Center Hospital

• Ishihara J

  Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca

• Matsushima Y

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

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