Intratumoral Administration of Tumor Necrosis Factor-α for Malignant Gliomas : Two Case Reports
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概要
- 論文の詳細を見る
Two patients with histologically verified glioblastoma multiforme and anaplastic astrocytoma were treated with four courses of intratumoral administration of human natural tumor necrosis factor-α (TNF) (specific activity 2.0×10^6 Japan reference unit [JRU]/mg protein) at intervals of 3-5 months. Each consisted of eight to 10 serial injections, ranging from 5×10^3 to 10^4 JRU/injection, at intervals of 3-5 days. There was no simultaneous administration of steroids. Serial neurological examinations and neuroimaging studies with computed tomography and magnetic resonance imaging demonstrated partial responses ranging from 28 and 36 months in duration. No significant TNF-related brain edema, intracerebral bleeding, or neurotoxicity occurred. Local immunotherapy with TNF may be used safely to contribute to therapeutic efficacy.
- 日本脳神経外科学会の論文
- 1994-04-15
著者
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FUKUDA Minoru
Department of Medical Oncology, National Cancer Center Hospital
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Moritake Kouzo
Department of Neurosurgery, Shimane Medical University
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YAMASAKI Toshiki
Department of Neurosurgery, Shimane University School of Medicine
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Moritake Kouzo
Department Of Neurosurgery Kyoto University
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Yamasaki Toshiki
Department Of Neurosurgery Shimane Medical University
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Yamasaki Toshiki
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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PAINE Jonathan
Department of Neurosurgery, Shimane Medical University
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OHTA Fumihito
Department of Neurosurgery, Shimane Medical University
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NAITOH Hiroki
Department of Neurosurgery, Shimane Medical University
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Ohta Fumihito
Department Of Neurosurgery Shimane Medical University
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Naitoh Hiroki
Department Of Neurosurgery Shimane Medical University
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Paine Jonathan
Department Of Neurosurgery Shimane Medical University
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Fukuda Minoru
Department Of Anatomy Kyorin University School Of Medicine
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