Calcium Crystal Deposition in the Ligamentum Flavum of the Lumbar Spine : Role of Sex Hormones and Transforming Growth Factor-β
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概要
- 論文の詳細を見る
We investigated histopathological and immunohistochemical properties of the ligamentum flavum of the lumbar spine with calcium crystal deposition. Ligamentum flavum of the lumbar spine containing calcium deposits were harvested from 41 surgical cases. Sections of the ligaments were immunostained for estrogen receptor (ER), progesterone receptor (PR), and transforming growth factor (TGF)-β. The results were compared with those of ligaments without calcium deposits. The elastic fibers of the ligament with calcium deposits showed marked degeneration (irregular arrangement and fragmentation of fiber bundles) and nodular lesions. Deposits of calcium crystals were present in these areas where elastic fibers were degenerated. Immunostaining for ER was positive in these areas, and PR as well as TGF-β-containing chondrocytes were detected around and within the calcified areas. TGF-β, ER and PR-containing chondrocytes appeared to precipitate deposition of calcium crystals in the nodular lesions of the degenerated lumbar ligamentum flavum. Our results suggest that TGF-β and sex hormones play a role in the calcification of the lumbar ligamentum flavum.
- 日本組織細胞化学会の論文
著者
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FUKUDA Masaru
Department of Pathology, Fukui Medical University
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BABA Hisatoshi
Department of Orthopaedic Surgery, University of Fukui
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Baba Hisatoshi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui University
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui Medical School
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Baba Hisatoshi
Department Of Orthopedic Surgery Fukui Medical University
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Fukuda M
Glycobiology Program Cancer Research Center The Burnham Institute
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YAYAMA TAKAFUMI
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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KOKUBO YASUO
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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Furusawa Nobuaki
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui
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Fukuda M
Department Of Surgical Pathology University Hospital Faculty Of Medicine University Of Fukui
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Kokubo Yasuo
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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Fukuda Masaru
Department Of Pathology Fukui Medical School
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Yoshizawa Kyoko
Departments of Orthopaedic Surgery, School of Medicine, Fukui Medical University
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Furusawa Nobuaki
Department Of Orthopaedics And Rehabilitation Medicine University Of Fukui
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Yayama Takafumi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Fukuda Minoru
Department Of Anatomy Kyorin University School Of Medicine
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine The University Of Fukui
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Yoshizawa K
Departments Of Orthopaedic Surgery School Of Medicine Fukui Medical University
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Fukuda Masaru
Department Of Anatomy Kyorin University School Of Medicine
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine Faculty Of Medical Sciences University Of Fukui
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