GROWTH AND FUNCTION OF THE PLACENTA : WITH SPECIAL REFERENCE TO VARIOUS ENZYMES INVOLVED IN THE BIOSYNTHESIS OF STEROIDS IN THE HUMAN PLACENTA
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概要
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To study the function of the placenta from the viewpoint of placental aging, we measured the activity of various enzymes, sulfatase, 3β-hydroxysteroid dehydrogenase + isomerase (3β-HSD) and aromatizing enzyme, which are involved in the synthesis of estrogen in the placenta, as well as placental RNA and DNA levels during gestation.Our results are as follow ; 1. Enzymes involved in estrogen synthesis in human placental villi. 1) Sulfatase activity (n mole/flask/10min) in each trimester was not significantly different (4.10±0.10 in the first, 3.40±0.49 in the second and 4.33±0.67 in the third).2) 3β-HSD activity (n mole/flask/10min) in each trimester was not significantly different (2.57±0.55 in the first, 2.70±0.30 in the second and 2.90±0.53 in the third).3) Aromatizing enzyme activity (n mole/flask/30min) in cytosome fraction in each trimester was not significantly different (1.80±0.28 in the first, 1.60±0.28 in the second and 2.401±0.28 in the third).However, in the total homogenate, it was significantly higher in the third trimester (6.27±0.25) than in the first (3. 83±0 .85) or second (3.40±0.14). 2. RNA and DNA concentrations in human placental villi.1) The RNA concentration (mg/g tissue) in each trimester was insignificantly different (2.48±0.20 in the first, 2.57±0.58 in the second and 2.63±0.42 in the third). However, the DNA concentration was significantly higher in the second (2.49±0.34) and third (2.42±0.45) trimesters than in the first (1.62±0.32).Although enzyme activity in the cytosome fraction does not change significantly, aromatizing enzyme activity in the total homogenate fraction, in which the heavy particulate contains the nuclei, is higher in the third trimester. The DNA concentration was significantly higher in the second and third trimesters.This indicates that aromatizing enzymes may be partly responsible for the increase in urinary estrogen as pregnancy progressed, and that the increase in aromatizing enzyme activity depends on the increase in the quantity of aromatizing enzyme, which in turn is dependent on the increase in the number of cell nuclei.
- 社団法人日本産科婦人科学会の論文
- 1986-03-01
著者
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FURUYA Hiroshi
Department of Built Engineering, Tokyo Institute of Technology
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FUKUDA Masaru
Department of Pathology, Fukui Medical University
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Furuya H
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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OKUYAMA Teruaki
Department of Obstetrics and Gynecology, Juntendo University School of Medicind
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Fukuda Masaru
Department Of Pathology Fukui Medical School
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Furuya Hiroshi
Department Of Architecture Faculty Of Engineering Kyushu Kyoritsu University
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Okuyama Teruaki
Department Of Obstetrics And Gynecology Juntendo University School Of Medicind
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Okuyama Teruaki
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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Fukuda Masaru
Department Of Anatomy Kyorin University School Of Medicine
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