Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation
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概要
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Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation : Qunwei ZHANG, et al. Department of Environment Health, Fukui Medical University-To study the lung acute and subacute toxicity of ultrafine nickel particles, rats were intratracheally instilled with 0, 0.1, 0.5, 1 and 5 mg ultrafine nickel (Uf-Ni), respectively. At 3 days after injection, the body weight and wet lung weight were determined. At the same time, bronchoalveolar lavage fluid (BALF) was analyzed for lactate dehydrogenase (LDH), total protein (TP), and total cell and differential cell counts. The results showed that indicators of lung injury and inflammation in BALF were markedly raised with increased Uf-Ni from 0 to 1 mg, and there were no differences in the indices between injection of Uf-Ni at 1 mg and at 5 mg. Rats were intratracheally instilled with 1 mg Uf-Ni, and wet lung weight, and bronchoalveolar lavage fluid (BALF) profiles were analyzed 1, 3, 7, 15 and 30 days later. The effects of Uf-Ni on indices that can be presumed to reflect epithelial injury and permeability (LDH or TP) were dramatically increased from day 1 up to 30 days after injection. Lung histology findings generally confirmed the BALF data, showing severe lung inflammation at 1 day after injection of Uf-Ni, and epithelial hyperplasia and inflammation still present at 30 days after injection. Our findings suggest that Uf-Ni causes persistent inflammation following instillation of a small dose.
- 社団法人日本産業衛生学会の論文
著者
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SATO Kazuhiro
Department of Environmental Health, School of Medicine, University of Fukui
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KUSAKA Yukinori
Department of Environmental Health, School of Medicine, University of Fukui
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FUKUDA Masaru
Department of Pathology, Fukui Medical University
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Donaldson K
Napier Univ. Gbr
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ZHANG Qunwei
Department of Environmental Health, School of Medicine, Fukui Medical University
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Kusaka Yukinori
Department Of Environmental Health Faculty Of Medical Sciences University Of Fukui
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Mo Yiqun
Department of Pathology, Fukui Medical School
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Mo Yiqun
Division Of Pulmonary And Critical Care Medicine Department Of Medicine New York University School O
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Zhang Qunwei
Department Of Environmental Health School Of Medicine Fukui Medical University:department Of Environ
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Fukuda Masaru
Department Of Pathology Fukui Medical School
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Fukuda Masaru
Department Of Pathology Fukui Medical University
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Sato Kazuhiro
Department Of Condensed Matter Physics The Institute Of Scientific And Industrial Research (isir) Os
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DONALDSON Kenneth
Department of Biological Sciences, Napier University
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佐藤 一博
Department Of Environmental Health School Of Medicine University Of Fukui
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Fukuda Masaru
Department Of Anatomy Kyorin University School Of Medicine
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Sato Kazuhiro
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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