Determination of the Platelet Activating Factor in Silicotic Patients and its Effect on Fibroblasts
スポンサーリンク
概要
- 論文の詳細を見る
Platelet-activation factor (PAF), one of the potent proinflammatory mediators, is produced from a large range of cells, including polymorphonuclear neutrophils, monocytes, and natural killer cells. To study the role of PAF in the pathogenesis of silicosis, we determined the PAF in silicotic patients and in healthy persons. The results showed that the concentration of PAF in the plasma of silicotic patients was significantly higher than that of healthy persons. Our in vitro experimental results showed that the total numbers of fibroblasts were markedly raised with added PAF from 0 to 1μg/ml. Adding 1μg/ml PAF significantly increased the total numbers of fibroblasts after culture for 48, 72, 96 hrs. Therefore, we suggest that PAF be possibly involved in the pathogenesis of silicosis. However, the mechanism remains to be further elucidated.
- 日本衛生学会の論文
著者
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ZHU Xinqiang
Department of Environmental Health, School of Medicine, Fukui Medical University
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Mo Yiqun
Division Of Pulmonary And Critical Care Medicine Department Of Medicine New York University School O
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Zhu Xinqiang
Department Of Environmental Health School Of Medicine Fukui Medical University
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Zhang Qunwei
Department Of Environmental Health School Of Medicine Fukui Medical University:department Of Environ
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ZHANG Qunwei
Institute of Hygiene, Zhejiang Academy of Medical Sciences
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MO Yiqun
Pharmacy College, The Ohio State University
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LOU Jinpin
Institute of Hygiene, Zhejiang Academy of Medical Sciences
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CHEN Zhimin
Children's Hospital, School of Medicine, Zhejiang University
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HE Linyun
Institute of Hygiene, Zhejiang Academy of Medical Sciences
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ZHONG Huixian
Institute of Hygiene, Zhejiang Academy of Medical Sciences
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Zhong Huixian
Institute Of Hygiene Zhejiang Academy Of Medical Sciences
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Lou Jinpin
Institute Of Hygiene Zhejiang Academy Of Medical Sciences
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He L
Institute Of Hygiene Zhejiang Academy Of Medical Sciences
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Chen Zhimin
Children's Hospital School Of Medicine Zhejiang University
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Zhu Xinqiang
Department Of Toxicology
関連論文
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