Dynamic Changes of Constituents in Bronchoalveolar Lavage Fluid in Experimental Silicotic Rats
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概要
- 論文の詳細を見る
Bronchoalveolar lavage (BAL) is a useful and safe method for sampling cellularand biochemical components from the lung. Analysis of bronchoaveolar lavage fluid (BALF)constituents is useful for defining the stage of disease and for assessing disease progression and the response to therapy in lung disorders. We studied the dynamic changes in variousindices for BALF and the accompanying silicotic changes in the lungs of rats at different times after quartz instillation. Total cell counts, LDH activity, protein concentration and lipoperoxide (LPO) in the BALF of experimental silicotic rats were significantly higher thanthose of control rats (p < 0.05 or 0.01). After instillation, quartz content, total cell counts, LDH activity and protein concentration in BALE tended to decrease over time. Thesefindings suggested that in acute silicosis, quartz can induce serious inflammatio and damage the lung, with acute lung proteinosis seen as the main change in this stage.
- 労働省産業医学総合研究所の論文
著者
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Kusaka Yukinori
Department Of Environmental Health Faculty Of Medical Sciences University Of Fukui
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Zhang Qunwei
Department Of Environmental Health School Of Medicine Fukui Medical University:department Of Environ
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Sato Kazuhiro
Department Of Condensed Matter Physics The Institute Of Scientific And Industrial Research (isir) Os
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ZHANG Qunwei
Institute of Hygiene, Zhejiang Academy of Medical Sciences
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佐藤 一博
Department Of Environmental Health School Of Medicine University Of Fukui
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ZHANG Qifeng
Department of Occupational Health, Zhejiang MedicalUniversity
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He Linyuan
Institute of Occupational Health,Zhejiang Academy ofMedical Sciences
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He Linyuan
Institute Of Occupational Health Zhejiang Academy Ofmedical Sciences
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ZHANG Zhaohe
Institute of Occupational Health,Zhejiang Academyof Medical Sciences
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Sato Kazuhiro
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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