Infrared absorption study of human proinsulin C-peptide fragments in dichloromethane.
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概要
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In connection with the relationship between the conformation and solubility of peptide intermediates having polar side chains, IR spectroscopic conformational analysis of human proinsulin C-peptide fragments was performed in dichloromethane. The polar amino acid residues involved in the peptide fragments are Glu(OBzl), Asp(OBzl), Gin, and Ser(Bzl). Especially, the N–H stretching absorption spectra have been explored over a wide range of concentration. Based on the concentration dependence of the N–H stretching bands, it has been shown that the characteristic N–H stretching band around 3330 cm<SUP>−1</SUP> is due to the intramolecular hydrogen bond. Intermolecular hydrogen bonding also occurs to a small extent in these peptides, giving rise to a slight concentration dependence of the N–H stretching bands. Conformational behaviors of oligopeptides having protected polar side chains of the Glu(OBzl) and Asp(OBzl) residues are just the same as those of the corresponding homooligo(Leu)s, indicating that the protected polar side chains do not disturb conformational behaviors of the oligopeptides. Conformational analysis of the peptide in dichloromethane, which contains the Pro residue and has a high potential for the formation of an α-helical structure, distinctly suggests that the Pro residue near the N-terminal in the peptide has the great ability to promote successive intramolecular hydrogen bonds, probably corresponding to the α-helical structure of the peptide.
- 公益社団法人 日本化学会の論文
著者
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Narita Mitsuaki
Department Of Biotechnology And Life Science Faculty Of Technology Tokyo University Of Agriculture A
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Honda Shinya
Department Of Biological Science And Technology And Tissue Engineering Research Center Tokyo Univers
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Ogura Toshihiko
Department Of Developmental Neurobiology Institute Of Development Aging And Cancer Tohoku University
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Sato Kazuhiro
Department Of Condensed Matter Physics The Institute Of Scientific And Industrial Research (isir) Os
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Sato Kazuhiro
Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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Sato Kazuhiro
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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