Conformations in the solid state and solubility properties of protected homooligopeptides of glycine and .BETA.-alanine.

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概要

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• IR spectroscopic conformational analyses of Boc–Gly<I><SUB>n</SUB></I>–OBzl (<I>n</I>=3–7) and Boc–(β-Ala)<I><SUB>n</SUB></I>–OBzl (<I>n</I>=3–8) were performed in the solid state, suggesting the occurrence of the β-sheet structure in the higher oligomers (<I>n</I>=5–8). Solubility data indicate that insolubilities of Boc–Gly<I><SUB>n</SUB></I>–OBzl and Boc–(β-Ala)<I><SUB>n</SUB></I>–OBzl in high-polar solvents begin at hexa- and heptapeptide levels, respectively. Insolubility of protected homooligopeptides of Gly and β-Ala was estimated to be caused by β-sheet aggregation. The high potential for the β-sheet formation of Boc–Gly<I><SUB>n</SUB></I>–OBzl and Boc–(β-Ala)<I><SUB>n</SUB></I>–OBzl (<I>n</I>≥5) could clearly be attributed to the great freedom of the peptide backbone dihedral angles of each of the Gly and β-Ala residues in the β-sheet structure. The implications of a replacement of a few Gly residues with β-Ala residues in surface regions of proteins are also discussed.

• 公益社団法人 日本化学会の論文

著者

• Narita Mitsuaki

  Department Of Biotechnology And Life Science Faculty Of Technology Tokyo University Of Agriculture A

• Doi Masamitsu

  Department Of Materials Science Wakayama National College Of Technology

• Kudo Koji

  Department Of Physical Electronics Tokyo Institute Of Technology

• Terauchi Yusuke

  Department Of Environmental Studies Graduate School Of Frontier Sciences The University Of Tokyo

• Terauchi Yusuke

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• Kudo Koji

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• Kudo Koji

  Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo

• Doi Masamitsu

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• KUDO Koji

  Department of Applied Chemistry, Faculty of Engineering, Kanagawa University

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