The .BETA.-sheet structure-disrupting potential of electron-donor and -acceptor solvents and role of mixed solvents in solvation of peptides.
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概要
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The β-sheet structure-disrupting potential of hydrogen-donor and -acceptor solvents was in the good relationship with their electron-acceptor and -donor numbers (AN and DN), respectively. As AN and DN of solvents are larger, their β-sheet structure-disrupting potential becomes higher. Based on the results of the β-sheet structure disruption in the three component solvent system, it can also be clarified that combinations of homogeneous solvents are suitable for peptide and protein synthesis, but those of heterogeneous ones are not effective. The results of this study are of quite significance for the search for effective solvents in peptide and protein synthesis.
- 公益社団法人 日本化学会の論文
著者
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Narita Mitsuaki
Department Of Biotechnology And Life Science Faculty Of Technology Tokyo University Of Agriculture A
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Honda Shinya
Department Of Biological Science And Technology And Tissue Engineering Research Center Tokyo Univers
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Obana Satoshi
Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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Narita Mitsuaki
Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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