The electron donor-acceptor interaction between mixed solvents and its influence on their .BETA.-sheet strucutre-disrupting potential.

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概要

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• Cross-linked polystyrene resin-bound peptides were useful for the investigation of the β-sheet structure-disrupting potential of mixed solvents although their β-sheet structure-disrupted behavior by mixed solvents was different from that of peptides free from a macromolecular protecting group due to the concentrating efficacy of a cross-linked resin. In mixed solvents, the electron-acceptor and -donor numbers (AN and DN) of organic solvents were one of the most important factors to estimate their β-sheet structure-disrupting potential. In a mixture of electron-acceptor solvents themselves or -donor solvents, the electron donor-acceptor interaction between solvents did not occur and electron-accepting or -donating property of each solvent was kept to disrupt the β-sheet aggregation in mixed solvents. On the other hand, in a mixture of electron-acceptor solvent and -donor solvent, the electron donor-acceptor interaction between solvents occurred predominantly to decrease the β-sheet structure-disrupting potential of mixed solvents. The present results clarify the criteria of the search for effective solvents in peptide and protein synthesis.

• 公益社団法人 日本化学会の論文

著者

• Narita Mitsuaki

  Department Of Biotechnology And Life Science Faculty Of Technology Tokyo University Of Agriculture A

• Honda Shinya

  Department Of Biological Science And Technology And Tissue Engineering Research Center Tokyo Univers

• Sasaki Chie

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• Sasaki Chie

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• Kakei Hideaki

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• Isokawa Shizuko

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

• Umeyama Hiroshi

  Department of Industrial Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology

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