Tumor Necrosis Factor-Alpha Release from Rat Pulmonary Leukocytes Exposed to Ultrafine Cobalt : in vivo and in vitro Studies
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概要
- 論文の詳細を見る
Ultrafine cobalt (Uf-Co), one of the new category of ultrafine particles, is generated in some industrial situations and it also exists in environmental particles. The aim of this study was to investigate the ability of rat pulmonary leukocytes to release tumor necrosis factor alpha (TNF-alpha) after exposure to Uf-Co in vivo and in vitro. Rats were intratracheally instilled with 1 mg of Uf-Co, and then wet lung weight and bronchoalveolar lavage fluid (BALF) profile were analysed 1, 3, 7, 15, and 30 days later. The effects of Uf-Co on indices that can be presumed to reflect epithelial injury and permeability (lactate dehydrogenase (LDH) and total protein (TP)) were increased throughout the 30 day post-exposure period. Furthermore, at 3 days after exposure, leukocytes were collected by bronchoalveolar lavage (BAL). After 3, 6, 12, 24, 48, and 72 hours of incubation, TNF-alpha in supernatants were determined by ELISA method. The results showed that TNF-alpha secretion by activated leukocytes from rats instilled with Uf-Co was significantly higher than that of the controls. BAL leukocytes from the lung of exposed rats revealed time-and dose-related increases in TNF-alpha release. In conclusion, our results reveal, for the first time to our knowledge, that exposure to Uf-Co can stimulate leukocytes to secrete TNF-alpha. These data suggest that the TNF-alpha release from pulmonary leukocytes probably plays a role in the pathogenesis of "cobalt lung".
- 日本衛生学会の論文
著者
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Donaldson K
Napier Univ. Gbr
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Kusaka Yukinori
Department Of Environmental Health Faculty Of Medical Sciences University Of Fukui
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Zhang Qunwei
Department Of Environmental Health School Of Medicine Fukui Medical University:department Of Environ
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Sato Kazuhiro
Department Of Condensed Matter Physics The Institute Of Scientific And Industrial Research (isir) Os
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DONALDSON Kenneth
Department of Biological Sciences, Napier University
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佐藤 一博
Department Of Environmental Health School Of Medicine University Of Fukui
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WANG Deweng
Department of Environmental Health, School of Medicine, Fukui Medical University
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Wang Deweng
Department Of Environmental Health School Of Medicine Fukui Medical University
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Sato Kazuhiro
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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