Herniated and Spondylotic Intervertebral Discs of the Human Cervical Spine: Histological and Immunohistochemical Observations
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the histological and immunohistochemical changes within and around the cervical intervertebral discs in symptomatic myeloiradiculopathy and myelopathy patients. A total of 163 cervical intervertebral discs, 100 herniated discs and 63 spondylotic discs, were harvested en bloc during anterior decompressive surgeries and histological examination was performed, focusing on nucleus pulposus, annulus fibrosus, cartilaginous endplate, and ligamentous enthesis. There was a close relationship between MRI grade and histological degenerative changes. Histological features of the herniated intervertebral discs were the presence of granulation tissue, newly-developed blood vessels and infiltration of CD68-positive cells, which surrounded the herniated tissue in the outer layer of the annulus fibrosus. Marked vascular invasion was detected in 67% of herniated discs and 54% of spondylotic discs. Immunohistochemically, chondrocytes positive for matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) were detected in both herniated and spondylotic discs. Our results indicate that the neoangiogenesis process is associated with overexpression of bFGF and VEGF, and suggest that intervertebral disc degradation is enhanced by macrophage infiltration, which is regulated by MMP-3 and TNF-α. The expression of these proteins may be enhanced by the tear of annulus fibrosus.
- 日本組織細胞化学会の論文
著者
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FUKUDA Masaru
Department of Pathology, Fukui Medical University
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BABA Hisatoshi
Department of Orthopaedic Surgery, University of Fukui
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IMAMURA Yoshiaki
Division of Surgical Pathology, Faculty of Medical Sciences, University of Fukui
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KOBAYASHI Shigeru
Department of Human Geography, Graduate School of Letters, Osaka University
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Noriki Sakon
Division Of Tumor Pathology Department Of Pathological Sciences Faculty Of Medical Sciences Universi
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Noriki Sakon
Department Of Pathology Fukui Medical University
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Baba Hisatoshi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui University
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui Medical School
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Baba Hisatoshi
Department Of Orthopedic Surgery Fukui Medical University
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Fukuda M
Glycobiology Program Cancer Research Center The Burnham Institute
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IMAMURA Yoshiaki
Department of Pathology, University of Fukui
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UCHIDA Kenzo
Department of Urology, Tokyo Metropolitan Government Officials Mutual Aid Association Aoyama Hospita
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NAKAJIMA HIDEAKI
Department of Internal Medicine, Division 1, Kobe Medical College
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Noriki Sakon
First Department Of Pathology Fukui Medical University
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YAYAMA TAKAFUMI
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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KOKUBO YASUO
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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NEGORO KOHEI
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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FUJIMOTO Michiyo
Department of Orthopaedic Surgery, Fukui University
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Furusawa Nobuaki
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui
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Kakuyama Michiko
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui
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Nakajima Hideaki
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Imamura Yoshiaki
Division Of Surgical Pathology Faculty Of Medical Sciences University Of Fukui
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Imamura Yoshiaki
Department Of Clinical Pathology University Of Fukui
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Kobayashi Shigeru
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Imamura Y
Tumour Pathology Fukui University Faculty Of Medical Sciences
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Fukuda M
Department Of Surgical Pathology University Hospital Faculty Of Medicine University Of Fukui
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Kokubo Yasuo
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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Uchida Kenzo
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Uchida Kenzo
Department Of Endocrinology Kanazawa Medical University
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Negoro Kohei
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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Fukuda Masaru
Department Of Pathology Fukui Medical School
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Furusawa Nobuaki
Department Of Orthopaedics And Rehabilitation Medicine University Of Fukui
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Yayama Takafumi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Fukuda Minoru
Department Of Anatomy Kyorin University School Of Medicine
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Kakuyama Michiko
Department Of Orthopaedics And Rehabilitation Medicine University Of Fukui
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Fujimoto Michiyo
Departments Of Orthopaedics And Rehabilitation Medicine University Of Fukui
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Kumakiri Masanobu
Department Of Dermatology Fukui Medical University
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine The University Of Fukui
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Nakajima Hideaki
Department Of Dermatology Kochi Medical School Kochi University
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Kobayashi Shigeru
Deparment Of Oral Anatomy Kyushu Dental College
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Fukuda Masaru
Department Of Anatomy Kyorin University School Of Medicine
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine Faculty Of Medical Sciences University Of Fukui
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