Frequent detection of multidrug-resistant pneumonia-causing bacteria in the pneumonia lung tissues of patients with hematological malignancies

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概要

• 論文の詳細を見る

• Pneumonia is a critical issue during the agonal phase, and often becomes lethal in the absence of pathogen detection. Autopsy is a powerful tool for analyzing the cause of a patient's death, progression of the disease, and the therapeutic response. However, it is frequently limited to the identification of bacterial strains. To elucidate the pathogenesis during the agonal phase of pneumonia, intrapulmonary sputum was harvested by directly inserting a swab into a resected lung, and the bacterial composition was analyzed using both pathological and microbiological techniques from 15 patients with hematological malignancies, and the results were compared with those from 25 patients with other medical and surgical diseases. Among the 54 bacteria strains isolated from the 40 patients, multidrug-resistant strains were significantly more prevalent in hematological group than in other diseases (16/21 versus 11/33, P = .002). Enterococcus faecium was preferentially isolated from the hematological patients, whereas the methicillin-resistant Staphylococcus aureus was predominantly found in the nonhematological group. Two coagulase-negative Staphylococcus epidermidis strains in hematological diseases may be diagnosed as causative bacteria of pneumonia by both bacterial and pathological techniques. Although the results of this study may not be directly applicable for clinical diagnosis, this approach has a potential to become not only a diagnostic method for bacterial pneumonia, but may be also useful for the analysis of multidrug-resistant pathogens.

• Springerの論文
• 2007-10-15

著者

• Ueda Takanori

  福井大学 血液腫瘍内科学

• Ueda T

  Department Of Hematology And Oncology University Of Fukui

• Ueda T

  Department Of Urology Chiba Cancer Center

• Ueda T

  First Department Of Internal Medicine University Of Fukui

• INAI Kunihiro

  Divisions of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences,

• UEDA Takanori

  Divisions of Hematology and Oncology, Department of General Medicine, Faculty of Medical Sciences, U

• TAKIMOTO Nobuo

  Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, U

• IMAMURA Yoshiaki

  Division of Surgical Pathology, Faculty of Medical Sciences, University of Fukui

• NAIKI Hironobu

  Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, U

• NORIKI Sakon

  Division of Tumor Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, Unive

• IWASAKI Hiromichi

  Division of Hematology and Cardiology, University of Fukui, Faculty of Medical Sciences

• IKEGAYA Satoshi

  Division of Molecular Pathology, University of Fukui, Faculty of Medical Sciences

• YAMASHITA Masanori

  Division of Clinical Inspection, University of Fukui, Faculty of Medical Sciences

• IMAMURA Yoshiaki

  Diagnostic Pathology Division, University of Fukui, Faculty of Medical Sciences

• KATO Hisataka

  Division of Tumor Pathology, University of Fukui, Faculty of Medical Sciences

• Noriki Sakon

  Division Of Tumor Pathology Department Of Pathological Sciences Faculty Of Medical Sciences Universi

• Katoh Hisataka

  Dept. Of First Pathology Fukui Medical University

• Kato Hisataka

  Division Of Tumor Pathology University Of Fukui Faculty Of Medical Sciences

• Inai Kunihiro

  Division Of Molecular Pathology Department Of Pathological Sciences Faculty Of Medical Sciences Univ

• Takimoto Nobuo

  Division Of Molecular Pathology Department Of Pathological Sciences Faculty Of Medical Sciences Univ

• Naiki Hironobu

  Second Department Of Pathology University Of Fukui

• Naiki Hironobu

  Division Of Molecular Pathology Department Of Pathological Sciences Faculty Of Medical Sciences Univ

• Noriki Sakon

  First Department Of Pathology Fukui Medical University

• Imamura Yoshiaki

  Division Of Surgical Pathology Faculty Of Medical Sciences University Of Fukui

• Yamashita Masanori

  Division Of Clinical Inspection University Of Fukui Faculty Of Medical Sciences

• Imamura Y

  Tumour Pathology Fukui University Faculty Of Medical Sciences

• Ueda Takahiro

  First Department Of Internal Medicine Fukui Medical University Idarubicin Study Group

• Imamura Shin

  First Department Of Internal Medicine Fukui Medical University

• Iwasaki Hiromichi

  Department Of Hematology And Oncology University Of Fukui

• Ikegaya Satoshi

  Division Of Molecular Pathology University Of Fukui Faculty Of Medical Sciences

• Ueda Takanori

  Division Of Hematology And Oncology Faculty Of Medical Sciences University Of Fukui

• Ueda Takeshi

  Department Of Urology Chiba University Graduate School Of Medicine

• Naiki Hironobu

  Division Of Molecular Pathology Department Of General Medicine Faculty Of Medical Sciences University Of Fukui

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