Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1
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概要
- 論文の詳細を見る
The majority of primary central nervous system lymphomas (PCNSL) are diffuse large B-cell lymphomas. Histologically, reactive T lymphocytes and monohistiocytic cells are found within PCNSL tissue. To clarify the mechanisms of the cellular infiltration, the presence of monocyte chemoattractant protein (MCP-1) was investigated in biopsy samples of 19 cases of PCNSL by means of immunohistochemical staining, double staining with a confocal laser microscope, and Western blot analysis. MCP-1 expression was observed in all PCNSL immunohistochemically. Western blot analysis showed that the concentration of MCP-1 in PCNSL was as high as that in a metastatic brain tumor. In normal brain tissue, MCP-1 was not detected. Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL.
- Springerの論文
- 2007-03-01
著者
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Sato Kazufumi
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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IMAMURA Yoshiaki
Division of Surgical Pathology, Faculty of Medical Sciences, University of Fukui
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KUBOTA Toshihiko
Department of Neurosurgery, University of Fukui
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MATSUMOTO Hideki
Department of Physics,The University of Alberta
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Kubota Toshihiko
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Kubota Toshihiko
Department Of Neurosurgery Fukui Medical School
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Kubota Toshihiko
Department Of Neurosurgery Kaga Central Hospital
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Sakuma Takahiro
Department Of Aging Medicine And Geriatrics Shinshu University School Of Medicine
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Sakuma Takahiro
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Sato K
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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KITAI Ryuhei
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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ISHISAKA Kazuyo
Medical Sciences, University of Fukui
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YAMAUCHI Takahiro
Medical Sciences, University of Fukui
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Kodera Toshiaki
Department Of Neurosurgery Sugita Genpaku Memorial Obama Municipal Hospital
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Matsumoto Hideki
Department Of Physics The University Of Alberta
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Imamura Yoshiaki
Division Of Surgical Pathology Faculty Of Medical Sciences University Of Fukui
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Yamauchi Takahiro
Medical Sciences University Of Fukui
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Kitai Ryuhei
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Ishisaka Kazuyo
Medical Sciences University Of Fukui
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Kubota Toshihiko
Department Of Internal Medicine Kitasato University School Of Medicine
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Matsumoto Hideki
Department Of Anatomy Nara Medical University
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Kubota Toshihiko
Department Of Neurosurgery Sugita Genpaku Memorial Obama Municipal Hospital
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Matsumoto Hideki
Department Of Experimental Radiology And Health Physics Faculty Of Medical Sciences University Of Fu
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Matsumoto Hideki
Department Applied Physics Seikei University:(present Address)institute Of Physics University Of Tsu
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