Epstein-Barr Virus-Associated Primary Central Nervous System Lymphoma in the Japanese Population
スポンサーリンク
概要
- 論文の詳細を見る
The incidence of Epstein-Barr virus (EBV)-associated primary central nervous system (CNS) lymphoma in Japan was assessed using in situ hybridization of EBV-encoded small ribonucleic acid-1 (EBER-1) to identify the presence of EBV in 22 cases of formalin-fixed and paraffin-embedded primary CNS lymphoma. All cases were B-cell lymphoma. EBER-1 expression was observed in the nuclei of 3 of 22 primary CNS lymphoma cases (13.6%). The incidence of EBV-positive lymphoma in Japanese cases is higher than previously reported from Western countries. Patients with EBV-positive primary CNS lymphoma showed shorter survival than those with negative tumors (median 4 months vs. 26 months). EBER-1 in situ hybridization for the detection of EBV infection is rapid and reliable. Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors.
- 社団法人 日本脳神経外科学会の論文
- 2010-02-15
著者
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SAITO Yasushi
Department of Clinical Cell Biology Graduate School of Medicine, Chiba University
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Takeuchi Hiroaki
Department of Oral Health, National Institute of Public Health
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Saito Yasushi
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Sato Kazufumi
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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IMAMURA Yoshiaki
Division of Surgical Pathology, Faculty of Medical Sciences, University of Fukui
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KUBOTA Toshihiko
Department of Neurosurgery, University of Fukui
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Takeuchi Hiroaki
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Kubota Toshihiko
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Kubota Toshihiko
Department Of Neurosurgery Fukui Medical School
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Kubota Toshihiko
Department Of Neurosurgery Kaga Central Hospital
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Sato K
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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KITAI Ryuhei
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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MATSUDA Ken
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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ADACHI Erika
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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NAKAJIMA Tsuyoshi
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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Kodera Toshiaki
Department Of Neurosurgery Sugita Genpaku Memorial Obama Municipal Hospital
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Imamura Yoshiaki
Division Of Surgical Pathology Faculty Of Medical Sciences University Of Fukui
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Matsuda Ken
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Kitai Ryuhei
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Adachi Erika
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Kubota Toshihiko
Department Of Internal Medicine Kitasato University School Of Medicine
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Kubota Toshihiko
Department Of Neurosurgery Sugita Genpaku Memorial Obama Municipal Hospital
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Nakajima Tsuyoshi
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Nakajima Tsuyoshi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Takeuchi Hiroaki
Department Of Clinical Laboratory Medicine Kochi Medical School
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Saito Yasushi
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Takeuchi Hiroaki
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Saito Yasushi
Department Of Cardiology Juntendo University School Of Medicine
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Nakajima Tsuyoshi
Department Of Chemistry And Material Engineering Faculty Of Engineering
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Nakajima Tsuyoshi
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
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