Synapse Involvement of the Dorsal Horn in Experimental Lumbar Nerve Root Compression : A Light and Electron Microscopic Study
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概要
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Study Design. This study was aimed at investigating changes in the dorsal horn of the lumbar cord induced by mechanical compression using an in vivo model. Objective. To determine the effect of axonal flow disturbance in the dorsal horns induced by nerve root compression. of Background Data. Few studies have looked at changes of synapses within the dorsal horn caused by disturbance of axonal flow and the axon reaction as a result of mechanical compression of the dorsal root. Methods. In mongrel dogs, the 7th lumbar nerve root was compressed for 1 week, or 3 weeks using a clip. After intravenous injection of Evans blue albumin, they were observed under a fluorescence microscope for the purpose of clarifying the function of the blood-spinal cord barrier. Morphologic changes of the synapses in the dorsal horns secondary to the nerve fiber degeneration were examined by light and electron microscope. Changes on immuno-staining for substance P, calcitonin gene-related peptide, and somatostatin in the dorsal horn were also examined. Results. Light microscope observation conducted 1 week after compression of the nerve roots revealed Wallerian degeneration of the myelinated nerve in the dorsal horn, and fluorescence microscope observation of these areas demonstrated edema formation resulting from damage of the blood-spinal cord barrier. Three weeks after the compression, electron microscope observation revealed shrinkage of the axon terminals, ubiquitous presence of high electron density degeneration and presence of synapses whose contact with synapses was disrupted. Immuno-histochemical studies showed a marked decrease of substance P, calcitonin gene-related peptide, and somatostatin staining in substance gelatinosa with Wallerian degeneration after compression of nerve root. Conclusion. It is important to recognize that compressive disturbance of the nerve roots caused Wallerian degeneration not only at the site of compression of nerve roots but also at the synapses of spinal cord dorsal horns.
- Lippincott, Williams & Wilkinsの論文
- 2008-04-01
著者
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Mwaka Erisa
Fukui Univ. School Of Medicine Fukui Jpn
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Mwaka Erisa
福井大学 医学部整形外科学
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Mwaka Erisa
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Miyazaki Tsuyoshi
Department of Biological and Environmental Engineering, The Graduate School of Agricultural and Life
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BABA Hisatoshi
Department of Orthopaedic Surgery, University of Fukui
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KOBAYASHI Shigeru
Department of Human Geography, Graduate School of Letters, Osaka University
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Baba Hisatoshi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui University
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Baba Hisatoshi
Department Of Orthopaedics And Rehabilitation Medicine University Of Fukui Faculty Of Medical Scienc
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Baba Hisatoshi
Department Of Orthopaedic Surgery Fukui Medical School
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Baba Hisatoshi
Department Of Orthopedic Surgery Fukui Medical University
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UCHIDA Kenzo
Department of Urology, Tokyo Metropolitan Government Officials Mutual Aid Association Aoyama Hospita
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NAKAJIMA HIDEAKI
Department of Internal Medicine, Division 1, Kobe Medical College
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YAYAMA TAKAFUMI
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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KOKUBO YASUO
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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TAKENO KENICHI
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
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Nakajima Hideaki
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Miyazaki Tsuyoshi
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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Kobayashi Shigeru
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Kokubo Yasuo
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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Uchida Kenzo
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Uchida Kenzo
Department Of Endocrinology Kanazawa Medical University
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Ueda Keiichi
Department Of Dermatology Fukui Medical University
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Takeno Kenichi
Department Of Orthopaedics And Rehabilitation Medicine Fukui University Faculty Of Medical Sciences
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NOMURA Eiki
Department of Orthopedic Surgery, Saitama Municipal Hospital
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Yayama Takafumi
Department Of Orthopedics And Rehabilitation Medicine Fukui University School Of Medicine
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Nomura Eiki
Department Of Orthopaedics And Rehabilitation Medicine The University Of Fukui
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Takeno Kenichi
Department Of Orthopaedics And Rehabilitation Medicine Faculty Of Medical Sciences The University Of
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine The University Of Fukui
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Nakajima Hideaki
Department Of Dermatology Kochi Medical School Kochi University
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Miyazaki Tsuyoshi
Department Of Biological And Environmental Engineering The Graduate School Of Agricultural And Life
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Kobayashi Shigeru
Deparment Of Oral Anatomy Kyushu Dental College
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Yayama Takafumi
Department Of Orthopaedics And Rehabilitation Medicine Faculty Of Medical Sciences University Of Fukui
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