SELECTIVE ALPHA-ADRENOCEPTOR BLOCKING ACTIONS OF A NEW DERIVATIVE OF 2-HALOGENOETHYLAMINE : 6-(2-BROMOETHYL)-10, 11-METHYLENEDIOXY-5, 6, 7, 8-TETRAHYDRODIBENZ[c, e]AZOCINE
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概要
- 論文の詳細を見る
A new compound, 6-(2-bromoethyl)-10, 11-methylenedioxy-5, 6, 7, 8-tetrahydrodibenz [c, e] azocine (DA-VIII-MBr) was found to have a more selective α-adrenergic blocking action than dibenamine or phenoxybenzamine. From dose-response curves for adrenaline and 5-hydroxytryptamine (5-HT) obtained in strips of rat aorta before and after incubation with each of the three blocking agents, the fractions of receptors remaining active for adrenaline and 5-HT, respectively, were estimated. After blockade with DA-VIII-MBr the receptors for adrenaline were blocked considerably, but those for 5-HT were little affected. Dibenamine blocked the receptors to adrenaline and 5-HT almost equally. The effective dose of phenoxybenzamine for adrenaline receptors was less than one hundredth that of dibenamine or DA-VIII-MBr, but specificity for these receptors was intermediate between those of dibenamine and DA-VIII-MBr. The structure of DA-VIII-MBr is an analog of apogalanthamine and its nitrogen atom bears the 2-halogenoethylamine group in part of an eight membered ring.
- 社団法人 日本薬理学会の論文
著者
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KOBAYASHI Shigeru
Department of Human Geography, Graduate School of Letters, Osaka University
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Ishida Yukio
Faculty Of Pharmaceutical Sciences The University Of Tokushima:faculty Of Home Economics Shikoku Wom
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Ishida Yukio
Department Of Electronic-mechanical Engineering School Of Engineering
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Kihara Masaru
Departments Of Pharmaceutical Chemistry Faculty Of Pharmacutical Sciences University Of Tokushima
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WATANABE Kouzo
Departments of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima
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Ishida Yukio
Department Of Chemical Pharmacology:faculty Of Pharmaceutical Sciences University Of Tokushima
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Kobayashi Shigeru
Deparment Of Oral Anatomy Kyushu Dental College
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ISHIDA Yukio
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima
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KOBAYASHI Shigeru
Departments of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima
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KIHARA Masaru
Departments of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima
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ISHIDA Yukio
Departments of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima
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ISHIDA YUKIO
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokushima
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