ALPHA-ADRENOLYTIC AND ANTI-SEROTONIN ACTIVITIES OF APOGALANTHAMINE ANALOGS ON THE RAT AORTIC STRIPS
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概要
- 論文の詳細を見る
Most of apogalanthamine analogs were more specific in a-adrenolytic activity than in anti-serotonin activity.^<1,2)> In this report, 1,2,11-trimethoxy-N-methy1-5,6,7,8-tetrahy-drodibenz [c, e] azocine (abbreviated as K-35) was found to be stronger in activity againstserotonin (pA_2=7.11±0.08) than against adrenaline (pA_2=6.24±0.06). Apogalanthamine analogs have a tetrahydrodibenz [c, e] azocine structure, in which one benzene can be regarded as a part of benzylamine and other as a part of phenethylamine. From the pharmacological point of view, various azocine compounds were tested, the phenethylamine in the azocine structure is demonstrated to contribute toward the α-adrenolytic activity and the benzylamine having two methoxy groups contributes toward the anti-serotonin activity.
- 公益社団法人日本薬学会の論文
著者
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Ishida Yukio
Faculty Of Pharmaceutical Sciences The University Of Tokushima:faculty Of Home Economics Shikoku Wom
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Ishida Yukio
Faculty Of Ceneral Education Nagoya University
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Kihara Masaru
Faculty Of Pharmaceutical Sciences The University Of Tokushima:faculty Of Home Economics Shikoku Wom
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KOBAYASHI Shigeru
Faculty of Pharmaceutical Sciences, The University of Tokushima
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SADAMUNE KIYOKO
Faculty of Pharmaceutical Sciences, University of Tokushima
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Sadamune Kiyoko
Faculty Of Pharmaceutical Sciences University Of Tokushima
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Kobayashi Shigeru
Faculty Of Pharmaceutical Sciences The University Of Tokushima:faculty Of Home Economics Shikoku Wom
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