ANTITUMOR ACTIVITY OF DERIVATIVES OF NEPLANOCIN A IN VIVO AND IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
Neplanocin A is a cyclopentenyl analog of adenosine which has been isolated from the culture filtrate of Ampullariella reqularis. Antitumor activity of twenty three derivatives of neplanocin A was examined against L1210,sarcoma 180 and L5178Y. Neplanocin A showed a marked inhibition of growth of L1210 in vivo. Other derivatives which had a 2' or 3'-substituted cyclopentene group showed weak cytotoxicity against L5178Y cells in vitro. Neplanocin A inhibited the biosynthesis of ribonucleic acid (RNA) and protein, while 6-chloroneplanocin A, a new active derivative, showed a specfic inhibition of only RNA synthesis. The two hydroxy groups in the cyclopentene moiety with a ribose type structure are important for marked antitumor activity.
- 社団法人日本薬学会の論文
著者
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Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
国立がんセンター
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Hoshi A
National Cancer Center Resarch Institute
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Iigo M
National Cancer Res. Inst. Tokyo
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Iigo Masaaki
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
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Iigo Masaaki
Pharmacology Division National Cancer Center Research Institute
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Iigo Masaaki
Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute
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Hoshi Akio
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij
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YOSHIDA MITSUZI
Pharmacology Division, National Cancer Center Research Institute
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TOKUZEN REIKO
Pharmacology Division, National Cancer Center Research Institute
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FUKUKAWA KIYOFUMI
Faculty of Pharmaceutical Sciences, Hokkaido University
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UEDA TOHRU
Faculty of Pharmaceutical Sciences, Hokkaido University
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YOSHIDA MITSUZI
National Cancer Center Research Institute
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Ishiguro Masaji
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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Tokuzen R
National Cancer Center Research Inst. Tokyo Jpn
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Yoshida Mitsuzi
Pharmacology Division National Cancer Center Research Institute
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Ueda T
Process Development Center Sharp Corporation
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Tokuzen Reiko
Pharmacology Division National Cancer Center Research Institute
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Fukukawa K
Toyo Jozo Co. Ltd. Shizuoka Jpn
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Ueda Tohru
Faculty Of Bioresource Sciences Akita Prefectural University
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YOSHIDA Mitsuzi
Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd. : Central Research Laboratories, Meiji Seika Kaisha, Ltd. : National Cancer Center Research Institute.
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